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| Research
Groups |
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Multifunctional RNP Research Group |
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Signal transduction RNP Research Group |
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Sites |
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Research Institute for Production Development (Kyoto) |
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Institute of Molecular and Cellular Biology, CNRS |
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| Research
Directors |
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Prof.Tan Inoue
Graduate School of Biostudies, Kyoto University |
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Prof. Eric Westhof
Director, Institute of Molecular and Cellular Biology, CNRS |
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The enormous volume of knowledge on biological molecules has been accumulated since the discovery of double-helical DNA. The trend of establishing a new field called “Synthetic Biology” is gaining momentum in this post-genome era. “Synthetic Biology” is expected to induce a new technology by practicing (re)design and (re)construction of biological molecules and biological systems.
The aim of this project is to develop a new basic technology for designing and constructing functional RNA and RNA-protein complex (RNP) molecules in order to regulate functions of a cell. The Japanese side conducts research on molecular design, construction and application, while the French side conducts research on structural biology, bioinformatics and molecular dynamics of RNA and RNP molecules. The ultimate goals are 1) to create multifunctional RNP molecules with tumor seeking sensors, imaging agents, and toxins that kill target cells, and 2) to establish artificial signal transduction systems for regulating functions of a cell by employing designed RNA and RNP molecules.
Prospective achievements of this project, such as a general method for designing and constructing functional RNA and RNP molecules, has potential for creating new diagnostic or therapeutic drugs and will have large impacts on the bionanotechnology field as well as the diagnostic and medical field.
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| Molecular design of RNA |
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| Molecular design of RNA-protein complex (RNP) |
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| Artificial information transduction cascade |
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