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| Research
Groups |
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Bacterial ATP-synthesis Regulation Group |
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Plant ATP-synthesis Regulation Group |
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Animal ATP-synthesis Regulation Group |
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National Museum of Emerging Science and Innovation |
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University of Otago |
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| Research
Directors |
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Prof. Masasuke Yoshida
Faculty of Engineering,Kyoto Sangyo University |
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Prof. Gregory Cook
Department of Microbiology & Immunology, University of Otago |
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ATP is a universal energy coin in all organisms. ATP synthesis is one of the most fundamental and dominant metabolisms in the biological world. A majority of ATP synthesis is carried out by an enzyme, ATP synthase. Energy supply for ATP synthesis and demands for ATP in cells vary depending on nutritional conditions and environments. Thus, ATP synthase needs to be regulated to meet these requirements; however, the mechanism of the regulation has been understood only poorly.
This project “ATP-synthesis regulation” aims to elucidate the regulatory mechanisms of ATP synthase and their physiological roles, thereby contributing to clear understanding of fundamental aspects of metabolism, development of self-regulatable nano-machines, and potential diseases caused by their defects. Japanese group will adopt in vitro approaches including biochemistry, genetics, protein chemistry, structural biology (crystallography and NMR), and single molecule observation and manipulation. Furthermore, the effects on living organisms will be investigated. New Zealand group will study physiological consequences of altered regulation systems of ATP synthase among a variety of microorganisms including pathogenic ones.
It is expected that this project will answer a fundamental question in bioenergetics, how ATP synthesis is regulated. The results will provide new information to control disorder of energy metabolism in our body.
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| Activity control mechanism of
bacterial ATP synthase |
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| Dimerization of mitochondrial ATP synthase by IF1 |
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| Oxidation-reduction control of chloroplast ATP synthase |
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