Publications
Original papers
2015
T. Negishi-Koga, HJ. Gober, E. Sumiya, N. Komatsu, K. Okamoto, S. Sawa, A. Suematsu, T. Suda, K. Sato, T. Takai & H. Takayanagi.
Immune complexes regulate bone metabolism through FcRγ signaling. Nat Commun. 2015 Mar 31. [Epub ahead of print]
T. Nitta, R. Muro, Y. Shimizu, S. Nitta, H. Oda, Y. Ohte, M. Goto, R. Yanobu, T. Narita, H. Takayanagi, H. Yasuda, T. Okamura, T. Murata, H. Suzuki.
The thymic cortical epithelium determines the TCR repertoire of IL-17-producing γδT cells. EMBO Rep. 2015 Mar 13. [Epub ahead of print] [PubMed]
K. Nishikawa, Y. Iwamoto, Y. Kobayashi, F. Katsuoka, S. Kawaguchi, T. Tsujita, T. Nakamura, S. Kato, M. Yamamoto, H. Takayanagi, M. Ishii.
DNA methyltransferase 3a regulates osteoclast differentiation by coupling to an S-adenosylmethionine-producing metabolic pathway. Nat Med. 21(3):281-7 (2015) [PubMed]
2014
H. Nakamura, T. Nakashima, M. Hayashi, N. Izawa, T. Yasui, H. Aburatani, S. Tanaka, H. Takayanagi.
Global epigenomic analysis indicates protocadherin-7 activates osteoclastogenesis by promoting cell–cell fusion. Biochem Biophys Res Commun. 455(3-4) 305-311 (2014) [PubMed]
N. Komatsu, K. Okamoto, S. Sawa, T. Nakashima, M. Oh-Hora, T. Kodama, S. Tanaka, J.A. Bluestone, H. Takayanagi.
Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis. Nat. Med. 20(1):62-8 (2014) [PubMed]
M. Shinohara, B.Y. Chang, J.J. Buggy, Y. Nagai, T. Kodama, H. Asahara, H. Takayanagi,
The orally available Btk inhibitor ibrutinib (PCI-32765) protects against osteoclast-mediated bone loss. Bone 60:8-15 (2014) [PubMed]
2013
J.I. Furusawa, K. Moro, Y. Motomura, K. Okamoto, J. Zhu, H. Takayanagi, M. Kubo, S. Koyasu.
Critical Role of p38 and GATA3 in Natural Helper Cell Function. J Immunol. 191(4):1818-26 (2013) [PubMed]
M. Oh-Hora, N. Komatsu,M. Pishyareh, S. Feske, S. Hori, M. Taniguchi, A. Rao, H. Takayanagi.
Agonist-Selected T Cell Development Requires Strong T Cell Receptor Signaling and Store-Operated Calcium Entry. Immunity. 38(5):881-95 (2013) [PubMed]
2012
M. A. A. Al-Bari, M. Shinohara, Y. Nagai, H. Takayanagi.
Inhibitory effect of chloroquine on bone resorption reveals the key role of lysosomes in osteoclast differentiation and function. Inflammation and Regeneration. 32(5):222-231 (2012) [PDF]
M. Shinohara, M. Nakamura, H. Masuda, J. Hirose, Y. Kadono, M. Iwasawa, Y. Nagase, K. Ueki, T. Kadowaki, T. Sasaki, S. Kato, H. Nakamura, S. Tanaka and H. Takayanagi.
Class IA phosphatidylinositol 3-kinase regulates osteoclastic bone resorption through Akt-mediated vesicle transport. J Bone Miner Res. 27(12):2464-75 (2012) [PubMed]
M. Hayashi, T. Nakashima, M. Taniguchi, T. Kodama, A. Kumanogoh and H. Takayanagi.
Osteoprotection by Semaphorin 3A. Nature. 485(7396):69-74 (2012) [PubMed]
K. Tsuji-Takechi, T. Negishi-Koga, E. Sumiya, A. Kukitae, S. Katof, T. Maedag, P. P. Pandolfi, K. Moriyama, and H. Takayanagi.
Stage-specific functions of leukemia/lymphoma-related factor (LRF) in the transcriptional control of osteoclast development. Proc Natl Acad Sci U S A. 109(7):2561-6(2012) [PubMed]
2011
T. Negishi-Koga, M. Shinohara, N. Komatsu, H. Bito, T. Kodama, R. H. Friedel, H. Takayanagi.
Suppression of bone formation by osteoclastic expression of semaphorin 4D. Nat Med. 17, 1473-80(2011) [PubMed]
T. Nakashima, M. Hayashi, T. Fukunaga, K. Kurata, M. Oh-hora, J. Q. Feng, L. F. Bonewald, T. Kodama, A. Wutz, E. F. Wagner, J. M. Penninger, H. Takayanagi.
Evidence for osteocyte regulation of bone homeostasis through RANKL expression. Nat Med. 17, 1231-34(2011) [PubMed]
S. Kuroda, M. Yamazaki, M. Abe, K. Sakimura, H. Takayanagi, Y. Iwai.
Basic leucine zipper transcription factor, ATF-like (BATF) regulates epigenetically and energetically effector CD8 T-cell differentiation via Sirt1 expression. Proc Natl Acad Sci U S A. 108(36): 14885-9 (2011) [PubMed]
A. Kamitani-Kawamoto, M. Hamada, T.Moriguchi, M. Miyai, F. Saji, I. Hatamura, K. Nishikawa, H. Takayanagi, S. Hitoshi, K. Ikenaka, T. Hosoya, Y. Hotta, S. Takahashi, K. Kataoka.
MafB interacts with Gcm2 and regulates parathyroid hormone expression and parathyroid development. J Bone Miner Res. 26(10): 2463-72 (2011) [PubMed]
E. Idrus, T. Nakashima, L. Wang, M. Hayashi, K. Okamoto, T. Kodama, N. Tanaka, T. Taniguchi, H. Takayanagi.
The role of the BH3-only protein Noxa in bone homeostasis. Biochem Biophys Res Commun. 410(3): 620-5 (2011) [PubMed]
2010
K. Nishikawa, T. Nakashima, S. Takeda, M. Isogai, M. Hamada, A. Kimura, T. Kodama, A. Yamaguchi, M. J. Owen, S. Takahashi, and H. Takayanagi.
Maf promotes osteoblast differentiation in mice by mediating the age-related switch in mesenchymal cell differentiation. J Clin Invest. 120(19): 3455-65(2010) [PubMed]
K. Okamoto,Y. Iwai, M. Oh-hora, M. Yamamoto, T. Morio, K. Aoki, K. Ohya, A. M. Jetten, S. Akira, T. Muta and H. Takayanagi.
IκBζ regulates TH17 development by cooperating with ROR nuclear receptors. Nature. 464, 1381-5 (2010) [PubMed]
M. Hayashi, T. Nakashima, T. Kodama, A. P. Makrigiannis, N. Toyama-Sorimachi, and H. Takayanagi.
Ly49Q, an ITIM-bearing NK receptor, positively regulates osteoclast differentiation. Biochem Biophys Res Commun.393, 432-8(2010) [PubMed]
K. Nishikawa, T. Nakashima, M. Hayashi, T. Fukunaga, S. Kato, T. Kodama, S. Takahashi, K. Calame, and H.Takayanagi.
Blimp1-mediated repression of negative regulators is required for osteoclast differentiation. Proc Natl Acad Sci U S A. 16:107(7), 3117-22(2010) [PubMed]
Review articles/Books
H. Takayanagi：SnapShot: Osteoimmunology.、Cell Metab. 21(3):502-502.e1. (2015)
H. Takayanagi：Osteoimmunology in 2014: Two-faced immunology-from osteogenesis to bone resorption.、Nat Rev Rheumatol., 11(2):74-6 (2015)
N. Komatsu, H. Takayanagi：Arthritogenic T cells in autoimmune arthritis.、Int J Biochem Cell Biol. 58:92-6 (2015)
2014
M. Shinohara, H. Takayanagi
Chapter14 : Analysis of NFATc1-Centered Transcription Factor Regulatory Networks in Osteoclast Formation.
Transcription Factor Regulatory Networks, Methods in Molecular Biology. 1164:171-6 (2014)
MM. Guerrini, H Takayanagi
The immune system, bone and RANKL.
Arch Biochem Biophys. 561: 1118-123 (2014)
2013
L. Danks, H. Takayanagi.
Immunology and bone. J Biochem. 154(1):29-39 (2013) [PubMed]
2012
T. Nakashima, H. Takayanagi, S. Choi(ed.).
RANK and RANKL.
Encyclopedia of Signaling Molecules mechanisms, 1581-1589 (2012)
H. Takayanagi
New developments in osteoimmunology.
Nat Rev Rheumatol. 8(11), 684-9 (2012)
T. Negishi-Koga, H. Takayanagi.
Bone cell communication factors and Semaphorins.
BoneKEy Reports 2012, 1, 183 (2012)
C. A. O'Briena, T. Nakashima and H. Takayanagi.
Osteocyte control of osteoclastogenesis. Bone. 54(2):258-63 (2012) [PubMed]
T. Nakashima, M. Hayashi, and H. Takayanagi.
New insights into osteoclastogenic signaling mechanisms. Trends Endocrinol Metab. 23(11):582-90 (2012) [PubMed]
N. Komatsu and H. Takayanagi.
Autoimmune arthritis: the interface between the immune system and joints. Adv. Immunol. 115:45-71 (2012) [PubMed]
N. Komatsu and H. Takayanagi.
Inflammation and bone destruction in arthritis: synergistic activity of immune and mesenchymal cells in joints. Front Immunol. 3:77(2012) [PubMed]
2011
T. Nakashima and H. Takayanagi
New regulation mechanisms of osteoclast differentiation.
Ann N Y Acad Sci., 1240(1), E13-8 (2011 Dec)
T. Nakashima and H. Takayanagi.
Osteoimmunology: the Effect of Inflammation on Bone.
Inflammation and Regeneration, 31(5), 404-412 (2011 Nov)
H. Takayanagi and I. Morita.
Introduction to the Special Issue "The Interaction Among Bone, Immunology and Vascular Biology"
Inflammation and Regeneration, 31(5), 399-403 (2011 Nov)
K. Okamoto and H. Takayanagi
Potential Molecular Targets for Suppressing Th17 development
Inflammation and Regeneration, 31(4), 354-360 (2011 Oct)
K. Okamoto and H. Takayanagi
Regulation of bone by the adaptive immune system in arthritis.
Arthritis Res. Ther., 13(3), 219 (2011 May)
2010
K. Okamoto and H. Takayanagi
Osteoclasts and interleukin-17-producing helper T cells in rheumatoid arthritis
Arthriris:Pathophysiology, Prevention and Therapeutics, 75-89 (2010 Nov)
K. Okamoto and H. Takayanagi
Osteoclasts in arthritis and Th17 cell development
International Immunopharmacology, 11(5), 543-8 (2010 Nov)
R. Faccio, Y. Choi, S. L. Teitelbaum, and H. Takayanagi
The Osteoclast: The Pioneer of Osteoimmunology
Osteoimmunology:Interactions of the Immune and Skeletal Systems, Academic Press, 141-185 (2010 Oct)
J. Lorenzo, Y. Choi, M. Horowitz and H. Takayanagi
Overview: The Developing Field of Osteoimmunology
Osteoimmunology:Interactions of the Immune and Skeletal Systems, Academic Press, 1-5 (2010 Oct)
H. Takayanagi
New Immune Connections in Osteoclast Formation
Ann. NY. Acad. Sci., 1192, 117-123 (2010 Mar)
H. Takayanagi
The Unexpected Link between Osteoclasts and the Immune System
Adv. Exp Med. Biol., 658, 61-69 (2010 Jan)
2009
H. Takayanagi
Osteoimmunology and the Effects of the Immune System on Bone
Nature Rev. Rheumatol., 5(12), 667-676 (2009 Dec)
