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ERATO
Exploratory Research for Advanced Technology 
戦略的創造研究推進事業(総括実施型研究)
創造科学犠実推進事業
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HOME > Research Projects > Post Project > YANAGISAWA Orphan Receptor
YANAGISAWA Orphan Receptor
Research Director: Masashi Yanagisawa
(Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center at Dallas)
Research Term 2001-2006
 
Outline of Research Results

  In 1998, we purified a novel neuropeptide orexin and showed that this peptide plays pivotal roles in the regulation of appetite and sleep. In this ERATO project, we showed that the administration of orexin could actually rescue the narcoleptic symptoms in orexin knockout mice.

  We also vigorously performed the “deorphanization” of orphan GPCRs during the project, and identified novel ligands for GPR103 and GPR7/8. We showed that the ligand of GPR103 has an essential function in regulating appetite and blood pressure. Through the analysis of knockout mice, we have clarified that the ligands for GPR7/8 (= NPB and NPW) have important roles in the homeostasis of the body, such as energy metabolism and stress responses.

   

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Exploratory Research for Advanced Technology 
戦略的創造研究推進事業(総括実施型研究)
創造科学技術推進事業 ERATO