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Electron Transfer System
Research Strategy
  Besides ATP synthase and V-ATPase, there are a variety of enegy-transducing supramolecular enzyme complexes in biological membranes, that provide a driving force for ATP synthase. In the respiratory and photosynthetic electron transfer systems, quinone redox reactions play a key role in energy transduction by NADH dehydrogenase(complex 1),succinate dehydrogenase(complex 2),and quinol oxidase(complex4). For understanding of their molecular mechanisms of redox reactions of quinones, intramolecular electron transfer and proton translocation,we are modifying the enzymes by site-directed mutagenesis,labeling with stable isotopes or with novel synthetic quione analogues, and studying their structures and functions by a variety of spectroscopic methods including X-ray crystallography.

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Sogo-Kenkyukan Bekkan, Tokyo Institute of Technology
Nagatsuta 4259, Midori-ku, Yokohama 226-8503, Japan

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Exploratory Research for Advanced Technology 
創造科学技術推進事業 ERATO