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ERATO
Exploratory Research for Advanced Technology 
戦略的創造研究推進事業(総括実施型研究)
創造科学犠実推進事業
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HOME > Research Projects > Post Project > SHINKAI Chemirecognics
SHINKAI Chemirecognics
Research Director: Dr.Seiji Shinkai
(Professor Faculty of Engineering Kyushu University)
Research Term 1990-1995
 
Outline of Research Results
 This project studied calixarenes and other compounds while aiming to establish 'artificial' high-precision chemirecognition systems comparable to those found in living systems. The establishment of a methodology for artificial recognition systems will make a substantial contribution to the creation of superior molecular sensors, artificial enzymes, new types of separation systems, and a variety of intelligent elements with high precision and selectivity, environmental resistance and wide utility.

Research Results

Sodium sensor with extraordinary selectivity: A synthesis of calixarenes that are highly selective for the sodium ion was achieved. Particularly noteworthy is a calix[4]crown derivative which shows sodium-ion selectivity of 105 against the potassium ion, i.e., two orders of magnitude higher than the previous world record (103), thus providing valuable information for designing highly selective ion sensors.

Novel lanthanide-based luminescence-emitting system: Calixarene derivatives were designed as ligands to form complexes with lanthanide ions. Several complexes with Tb or Eu were successfully synthesized which emit luminescence with extremely high quantum yields, representing a great contribution to designing organic luminescent elements with high quantum yields.

Saccharide-sensing system: A novel saccharide system has been established in which boronic acid moieties are utilized to recognize saccharide molecules and to read-out the recognition in the form of a physical signal: 1) Liquid crystal: The stability of the helical structure of a cholesteric liquid crystal is differently affected by the difference in the structure of an added saccharide/cholesterol boronic acid complex, thus producing a different color change which depends upon the type of saccharide in the complex. 2) Fluorescence: Novel compounds were synthesized which emit fluorescence upon binding to saccharides under neutral pH conditions. Even chiral discrimination of saccharides was achieved with a specific fluorescent diboronic compound, a world first. 3) Gelation: The gelation behaviors of saccharide/cholesterol phenylboronic acid complexes differ depending upon the type of the saccharide, a phenomenon which can be applied to the detection of saccharides.

Purification of fullerenes: It was found that the C60 fullerene can be separated from other fullerenes using a specific calixarene. Calix[8]arene forms a complex selectively with C60, resulting in a aggregated larger molecule that is easily precipitated, thus greatly reducing the separation costs and make the standard chromatographic method obsolete.

Molecular assemblies: The π-A isotherms of calixarene- or cholesterol-based amphiphilic compounds have demonstrated the selective recognition of metal ions and saccharide molecules, where the cholesterol-based amphiphilic compounds are of particular interest, because of the chiral discrimination of saccharides.

graph1

·A top view of C60inclued in calix[8]arene

graph2

·An intelligent liquid crystal to read out saccharide structure as color-change
 

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Exploratory Research for Advanced Technology 
戦略的創造研究推進事業(総括実施型研究)
創造科学技術推進事業 ERATO