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NAKAUCHI Stem Cell and Organ Regeneration
Research Director: Hiromitsu Nakauchi M.D.,Ph.D.
Professor, Center for Stem Cell and Regenetative Medicine,
Institute of Medical Science, The University of Tokyo
Research Term 2007-2012
Outline of Research

  Currently, organ failure (e.g., kidney, liver, heart) is treated either with an artificial organ or by organ transplantation. However, both approaches have fundamental problems such as medical cost, ethical issues, and absolute shortage of organ donors. As an alternative, regenerative medicine utilizing stem cells has been a focus of attention. Current stem cell therapy, however, mainly targets diseases that can be treated by cell transplantation. This is because organogenesis requires complex interactions among cells and organs during development, making regeneration of a solid organ effectively impractical to date.

  The goal of this project is to generate donor ES or iPS cell-derived solid organs in xenogenic animals using blastocyst complementation. The potential of this experimental system will be examined in large animal models. The results provided by this project should lead to better understanding of organogenesis and ultimately to generation of various solid organs to help patients with organ failure and to provide human materials for drug discovery and health-care related industries.

Research Director
Hiromitsu Nakauchi M.D.,Ph.D.
Research Groups
Small Animal Model Group Leader:
 Tomoyuki Yamaguchi
 Satoshi Yamazaki
 Sanae Hamanaka
 Hideki Masaki
 Toshihiro Kobayashi
Research assistant:
 Yuji Yamazaki
 Yukiko Wakiyama
 Mami Arai
 Hidemasa Sato
 Ayumi Umino
 Megumi Ito
 Chihiro Tamura
 Asako Ohshima
Large Animal Model Group Leader:
 Hiroshi Nagashima
 Masato Watanabe
Reseach Assistant:
 Syuko Takayanagi

Project Office
Amgen Holl,
4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, JAPAN
Research Manager:
 Motoo Watanabe
Administrative Manager:
 Atsumi Kozawa
 Futaba Matsuura
Phone: +81 (0) 3 5447 7771
FAX: +81 (0) 3 5447 7772

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