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ERATO
Exploratory Research for Advanced Technology 
戦略的創造研究推進事業(総括実施型研究)
創造科学犠実推進事業
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HOME > Research Projects > Ongoing Projects > NAKAUCHI Stem Cell and Organ Regeneration
NAKAUCHI Stem Cell and Organ Regeneration
Research Director: Hiromitsu Nakauchi M.D.,Ph.D.
Professor, Center for Stem Cell and Regenetative Medicine,
Institute of Medical Science, The University of Tokyo
Research Term 2007-2012
 
Outline of Research

  Currently, organ failure (e.g., kidney, liver, heart) is treated either with an artificial organ or by organ transplantation. However, both approaches have fundamental problems such as medical cost, ethical issues, and absolute shortage of organ donors. As an alternative, regenerative medicine utilizing stem cells has been a focus of attention. Current stem cell therapy, however, mainly targets diseases that can be treated by cell transplantation. This is because organogenesis requires complex interactions among cells and organs during development, making regeneration of a solid organ effectively impractical to date.

  The goal of this project is to generate donor ES or iPS cell-derived solid organs in xenogenic animals using blastocyst complementation. The potential of this experimental system will be examined in large animal models. The results provided by this project should lead to better understanding of organogenesis and ultimately to generation of various solid organs to help patients with organ failure and to provide human materials for drug discovery and health-care related industries.

 
Members
Research Director
Hiromitsu Nakauchi M.D.,Ph.D.
Research Groups
Small Animal Model Group Leader:
 Tomoyuki Yamaguchi
Researcher:
 Satoshi Yamazaki
 Sanae Hamanaka
 Hideki Masaki
 Toshihiro Kobayashi
Research assistant:
 Yuji Yamazaki
 Yukiko Wakiyama
 Mami Arai
 Hidemasa Sato
 Ayumi Umino
 Megumi Ito
 Chihiro Tamura
Assistant:
 Asako Ohshima
Large Animal Model Group Leader:
 Hiroshi Nagashima
Reseacher:
 Masato Watanabe
Reseach Assistant:
 Syuko Takayanagi


Project Office
Amgen Holl,
4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, JAPAN
STAFF
Research Manager:
 Motoo Watanabe
Administrative Manager:
 Atsumi Kozawa
Assistant:
 Futaba Matsuura
Contact
Phone: +81 (0) 3 5447 7771
FAX: +81 (0) 3 5447 7772
E-mail:


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JST 過去のお知らせはこちら ERATO
Exploratory Research for Advanced Technology 
戦略的創造研究推進事業(総括実施型研究)
創造科学技術推進事業 ERATO