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Exploratory Research for Advanced Technology 
戦略的創造研究推進事業(総括実施型研究)
創造科学犠実推進事業
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MURATA Lipid Active Structure
Research Director: Michio Murata
Professor, Department of Chemistry, Graduate School of Science, Osaka University
Research Term 2010-2015
 
Outline of Research

 Lipids are a main component of the biomembranes. Recently, membrane lipids have been shown to play key roles in cell physiology through interactions with proteins. On the other hand, structural biology, which has greatly accelerated the advance of biosciences, focuses largely on proteins and deals little with lipids and lipid ligands. Since lipids are highly flexible molecules, elucidation of their 3D structures upon binding to a receptor is extremely difficult even with X-ray crystallography.

  In this project, we will elucidate the active structure of lipids in and around proteins by means of solid-state NMR techniques combined with X-ray crystallography, organic synthesis and protein engineering. Function of lipids will be more profoundly understood in terms of their 3D structures. This breakthrough will advance our knowledge in biological and biomedical sciences over the next decade, thus eventually stimulating research and development in medical and pharmaceutical areas.

 
Members
Research Director
Dr.Michio Murata
Research Groups
Lipid molecules in biomembranes Group Leader:
 Michio Murata
Researcher:
 Toshiaki Hara
 Satoshi Kawatake
 Masanao Kinoshita
Ligand structures in membrane proteins Group Leader:
 Shigeru Matsuoka
Researcher :
 Sébastien Lethu
 Daisuke Matsuoka
 Jun Fukazawa
 Toshiyuki Yamaguchi
 Ligand active conformation Group Leader:
 Shigeru Sugiyama
Researcher:
 Mayumi Niiyama
 Mika Hirose


Project
Head Quarter
1-1 Machikaneyama, Toyonaka, Osaka 560-0043, Japan
STAFF
Project Coordinator
 Shigeru Matsuoka
Research Manager
 Fuminori Sato
Administrative Manager
 Keiichi Matsumoto
Administrative Staff
 Saori Ichino
Contact
Phone: (+)81-6-6850-5575
FAX: (+)81-6-6850-5573
E-mail:
matsumoto-k @ office.osaka-u.ac.jp


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Exploratory Research for Advanced Technology 
戦略的創造研究推進事業(総括実施型研究)
創造科学技術推進事業 ERATO