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KAWAOKA Infection-induced host responses
Research Director: Dr. Yoshihiro Kawaoka
Professor, Division of Virology, Institute of Medical Science University of Tokyo
Research Term 2008-2013
Outline of Research

  Viral infections have a tremendous impact on human health, yet little is known about the interactions between the pathogen and its host. We, therefore, propose a Systems Biology Approach to analyze virus infections in different biological systems, identify pathogen-host interactions, characterize host cell responses, and correlate these data with bioinformatics approaches. Influenza viruses are an ideal model system due to their impact on human health and the global economy. A ‘Virology/Cell Biology Unit’ will characterize influenza viral replication and pathogenicity in cells and animals and identify host-virus interaction partners. A ‘Host Cell Response Unit’ will study the cellular transcriptome in response to viral infection. Data analysis and modeling of cellular responses will be conducted by the ‘Computational Systems Biology Unit’. These studies will lead to a comprehensive understanding of the cellular networks activated upon viral infections and are, therefore, expected to establish new concepts in study of viral diseases.

Research Director
Dr. Yoshihiro Kawaoka
Research Groups
Virology/Cell Biology Group Leader:
 Shinji Watanabe
 Eiryo Kawakami
Research assistant:
 Naomi Fujimoto
 Yuriko Tomita
Host Cell Response Group Leader:
 Tokiko Watanabe
 Saori Sakaba
 Kazue Goto
Computational Systems Biology Group Leader:
 Hiroaki Kitano
 Yukiko Matsuoka
 Jason Shoemaker
 Tiago Lopes
Immunology Group Leader:
 Satoshi Fukuyama
Research assistant:
 Izumi Ishikawa

Project Office
4F, Second Bldg., The Institute of Medical Science, The University of Tokyo 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, JAPAN
Research Manager:
Tetsuzo Fukuda
Administrative Manager:
Masao Miyakawa
Kazumi Takamizawa

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