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戦略的創造研究推進事業(総括実施型研究)
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IWATA Human Receptor Crystallography
Research Director: Dr. So Iwata
(Professor, Division of Molecular Biosciences, Imperial College London)
Research Term 2005-2010
 
Outline of Research

  There is an expectation that the results from the human genome project can be exploited to lead to new drugs that are both more efficacious and less toxic than those currently on the market. One of the milestones to reaching this goal is to determine the structure of proteins targeted by drugs. Our project aims to establish a methodology for structure determination of human membrane proteins using X-ray crystallography. Despite being major drug targets, the high hydrophobicity of membrane proteins renders them difficult to crystallize. We will establish large-scale expression and purification methods to provide ample protein for high throughput crystallization screening. In addition a low-noise X ray data analysis system will be developed at a 3rd generation synchrotron to aid in the process of structure solution.

 
Members
Research Director
Dr. So Iwata
Research Groups
Receptor Production Group Group Leader:
 Takuya Kobayashi
Crystallization Group Group Leader:
 Takeshi Murata
Crystallizing Ligand Design Group Leader:
 Norimichi Nomura




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Exploratory Research for Advanced Technology 
戦略的創造研究推進事業(総括実施型研究)
創造科学技術推進事業 ERATO