村田脂質活性構造プロジェクト

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研究成果

他大学・企業との共同研究

ポリアミン関連タンパクの結晶解析

SCALAのX線レーザーを用いた構造解析

  1. Interaction analysis of a ladder-shaped polycyclic ether and model transmembrane peptides in lipid bilayers by using Forster resonance energy transfer and polarized attenuated total reflection infrared spectroscopy. Kazuya Yamada, Haruki Kuriyama, Toshiaki Hara, Michio Murata, Raku Irie, Yanit Harntaweesup, Masayuki Satake, Seketsu Fukuzawa, Kazuo Tachibana. Bioorg. Med. Chem. 2014, 22(14), 3773-3780. DOI: 10.1016/j.bmc.2014.04.044
  2. Confirmation of the absolute configuration at C45 of Amphidinol 3. Yoshiyuki Manabe, Makoto Ebine, Nobuaki Matsumori, Michio Murata, Tohru Oishi. J. Nat. Prod. 2012, 75(11), 2003-2006. DOI: 10.1021/np300604w
  3. Synthesis and structure revision of the C43-C67 Part of Amphidinol 3. Makoto Ebine, Mitsunori Kanemoto, Yoshiyuki Manabe, Yosuke Konno, Ken Sakai, Nobuaki Matsumori, Michio Murata, Tohru Oishi. Org Lett. 2013, 15(11), 2846-2849. DOI: 10.1021/ol401176a
  4. Direct and stereospecific interaction of amphidinol 3 with sterol in lipid bilayers. Rafael Atillo Espiritu, Nobuaki Matsumori, Masashi Tsuda, Michio Murata. Biochemistry 2014, 53(20), 3287-3293. DOI: 10.1021/bi5002932
  5. Design and synthesis of 24-fluorinated Bafilomycin analogue as an NMR Probe with potent inhibitory activity tovacuolar-type ATPase. Hajime Shibata, Hiroshi Tsuchikawa, Nobuaki Matsumori, Michio Murata, Takeo Usui. Chem. Lett. 2014, 43, 474-476. DOI: 10.1246/cl.131099
  6. Synthesis and biological evaluation of QRSTUVWXYZA′ domains of maitotoxin Kyriacos C. Nicolaou, Philipp Heretsch, Tsuyoshi Nakamura, Anna Rudo, Michio Murata, Keiichi Konoki. J. Am. Chem. Soc. 2014, 136(46), 16444-16451. DOI: 10.1021/ja509829e
  7. Crystallization and preliminary crystallographic studies of PotA, a membrane-associated ATPase of the spermidine-preferential uptake system in Thermotoga maritime. Shigeru Sugiyama, Keiko Kashiwagi, Keisuke Kakinouchi, Hideyuki Tomitori, Ken Kanai, Michio Murata, Hiroaki Adachi, Hiroyoshi Matsumura, Kazufumi Takano, Satoshi Murakami, Tsuyoshi Inoue, Yusuke Mori, Kazuei Igarashi. Acta Cryst. 2014, F70, 738-741. DOI: 10.1107/S2053230X14008607
  8. Expression, purification, crystallization and preliminary crystallographic analysis of spermidine acetyltransferase from Escherichia coli. Mayumi Niiyama, Shigeru Sugiyama, Mika Hirose, Sae Ishikawa, Hideyuki Tomitori, Kyohei Higashi, Tomoko Yamashita, Hiroaki Adachi, Kazufumi Takano, Satoshi Murakami, Michio Murata, Tsuyoshi Inoue, Yusuke Mori, Keiko Kashiwagi, Hiroyoshi Matsumura, Kazuei. Igarashi. Acta Cryst. 2013, F69, 884-887, DOI: 10.1107/S1744309113017132
  9. Grease matrix as a versatile carrier of proteins for serial crystallography. Michihiro Sugahara, Eiichi Mizohata, Eriko Nango, Mamoru Suzuki, Tomoyuki Tanaka, Tetsuya Masuda, Rie Tanaka, Tatsuro Shimamura, Yoshiki Tanaka, Chiyo Suno, Kentaro Ihara, Dongqing Pan, Keisuke Kakinouchi, Shigeru Sugiyama, Michio Murata, Tsuyoshi Inoue, Kensuke Tono, Changyong Song, Jaehyun Park, Takashi Kameshima, Takaki Hatsui, Yasumasa Joti, Makina Yabashi, So Iwata. Nature Methods, 2015, 12, 61-63 DOI: 10.1038/nmeth.3172