本文へジャンプ
HACHISU Masakazu

Education and Experience
Experience
2010 – present
JST, ERATO, Ito Glycotrilogy Project
2009 – 2010
AIST, Research Institute of Genome-based Biofactory
2008 – 2009
AIST, Drug-Seeds Discovery Research Laboratory
Education
2009 Ph.D. in Biological Science, Hokkaido University
2004 M.S. in Functional Polymer Science, Shinshu University

Research Fields
Recently, the carbohydrate chain is being focused on as the third chain molecule following nucleic acid and protein. Actually, the post-translational glycosylation is essential to the viability of eukaryote. The structural complexity and functional diversity of glycoconjugates attract our scientific curiosity, and also make it difficult for us to study the glycobiology. I expect that the chemistry makes large contributions to glycobiology. Organic synthesis makes it possible for us to produce the carbohydrate chain we want, and also create brand-new molecules such as probe, marker, toxin, drug and so on. I want to provide many findings to glycoscience from the standpoint of a chemist.

Publications
  1. K. Fujikawa, A. Koizumi, M. Hachisu, A. Seko, Y. Takeda, Y. Ito, “Construction of a High-Mannose-Type Glycan Library by a Renewed Top-Down Chemo-Enzymatic Approach”, Chem. Eur. J., 2015, 21, 3224–3233.
  2. M. Sakono, A. Seko, Y. Takeda, J. Aikawa, M. Hachisu, A. Koizumi, K. Fujikawa, Y. Ito, “Glycan specificity of a testis-specific lectin chaperone calmegin and effects of hydrophobic interactions”, Biochimica et Biophysica Acta (BBA) - General Subjects, 2014, 1840, 2904–2913.
  3. Y. Takeda, A. Seko, M. Hachisu, S. Daikoku, M. Izumi, A. Koizumi, K. Fujikawa, Y. Kajihara, Y. Ito, “Both Isoforms of Human UDP-glucose:glycoprotein Glucosyltransferase are Enzymatically Active”, Glycobiology, 2014, 24 (4), 344-350.
  4. K. Ohkawa, M. Hachisu, K. Devarayan, J. Araki, “Design and Synthesis of Peptide-Cellulose Conjugate Molecules –Aspects from Energy/Steric Profiles–”, Fibers Polym., 2013, 14 (12), 1970–1974.
  5. K. Ohkawa, M. Hachisu, T. Nomura, R. Arai, K. Hirabayashi, M. Tsukada, K. Abe, “Chain Conformational Study on Underwater Silk Proteins from Caddisfly, Stenopsyche marmorata –Implication of a Fiber-forming Mechanism–”, Adv. Mater. Res., 2013, 796, 3–8.

  6. A. Koizumi, I. Matsuo, M. Takatani, A. Seko, M. Hachisu, Y. Takeda, Y. Ito, “Top-down Chemo-enzymatic Approach to High-Mannose-Type Glycan Library: Synthesis of a Common Precursor and Its Enzymatic Trimming”, Angew. Chem. Int. Ed., 2013, 52 (29), 7426–7431.

  7. Y.Takeda, A. Seko, M. Sakono, M. Hachisu, A. Koizumi, K. Fujikawa, Y. Ito, “Parallel Quantification of Lectin–Glycan Interaction using Ultrafiltration”, Carbohydr. Res., 2013, 375, 112–117.

  8. K. Devarayan, M. Miyamoto, M. Hachisu, J. Araki, V. Periasamy, K. Ohkawa, “Cationic derivative of electrospun non-woven cellulose-chitosan composite fabrics for immobilization of aminoacylase-I”, Text. Res. J., 2013, 83 (18), 1918–1925.
  9. K. Devarayan, H. Hanaoka, M. Hachisu, J. Araki, M. Ohguchi, B. K. Bijoya, K. Ohkawa, “Direct Electrospinning of Cellulose-Chitosan Composite Nanofiber”, Macromol. Mater. Eng., 2013, 298 (10), 1059–1064.
  10. K. Devarayan, T. Hayashi, M. Hachisu, J. Araki, K. Ohkawa, “Correlations between steric/thermochemical parameters and O-/N-acylation reactions of cellulose” Carbohydr. Polym., 2013, 94, 468–478.
  11. K. Devarayan, M. Hachisu, J. Araki, K. Ohkawa, “Synthesis of peptide-cellulose conjugate mediated by a soluble cellulose derivative having b-Ala esters (II): Conjugates with O-phospho-L-serine-containing peptides”, Cellulose, 2013, 20 (1) 365–378.
  12. K. Ohkawa, M. Nishibayashi, K. Devarayan, M. Hachisu, J. Araki, “Synthesis of peptide-cellulose conjugate mediated by a soluble cellulose derivative having b-Ala esters”, Int. J. Biol. Macromol., 2013, 53, 150–159.
  13. M. Sakono, A. Seko, Y. Takeda, M. Hachisu, Y. Ito, “Biophysical properties of UDP-glucose:glycoprotein glucosyltransferase, a folding sensor enzyme in the ER, delineated by synthetic probes”, Biochem. Biophys. Res. Commun., 2012, 462 (4), 504–510.
  14. V. Periasamy, K. Devarayan, M. Hachisu, J. Araki, K. Ohkawa, “Chemical Modifications of Electrospun Non-woven Hydroxypropyl Cellulose Fabrics for Immobilization of Aminoacylase-I”, J. Fiber Bioeng. Inf., 2012, 5 (2), 191–205.
  15. K. Yamada, I. Nagashima, M. Hachisu, I. Matsuo, H. Shimizu, “Efficient solid-phase synthesis of cyclic RGD peptides under controlled microwave heating”, TetrahedronLett., 2012, 63 (9), 1066–1070.
  16. M. Hachisu, H. Hinou, M. Takamichi, S. Tsuda, S-I. Nishimura, “One-pot synthesis of cyclic antifreeze glycopeptides”, Chem. Commun., 2009, 1641–1643.
  17. D. Satoyoshi, M. Hachisu, M. Amaike, K. Ohkawa, H. Yamamoto, “Methionine-Containing Poly(amino acid) Hybrid Fibers via Self-Assembly at Aqueous Interface”, Macromol. Mater. Eng., 2004, 289 (6), 495–498.
  18. M. Hachisu, K. Ohkawa, H. Yamamoto, “Preparation of Silk-Like Fibers Designed by Self-Assembled Ionic Polypeptide”, Macromol. Biosci., 2003, 3 (2), 92–99.
  19. Y. Takahashi, M. Hachisu, K. Ohkawa, H. Yamamoto, “Water-Soluble Polypeptides at Aqueous Interface Produce Extensible Silk-Like Fiber”, Macromol. RapidCommun., 2002, 23 (9), 540–543.

Academic Society
･ The Chemical Society of Japan
･ The Society of Polymer Science, Japan
･ Japan Society for Bioscience, Biotechnology, and Agrochemistry
･ The Japanese Society of Carbohydrate Research
･ Forum: Carbohydrates Coming of Age (FCCA)
Others:
･ Hobbies; Driving a car, Riding a motorcycle
･ E-mail; hachisu[at]riken.jp

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