- 2010 – present
- JST, ERATO, Ito Glycotrilogy Project
- 2009 – 2010
- AIST, Research Institute of Genome-based Biofactory
- 2008 – 2009
- AIST, Drug-Seeds Discovery Research Laboratory
2009 Ph.D. in Biological Science, Hokkaido University
2004 M.S. in Functional Polymer Science, Shinshu University
- Recently, the carbohydrate chain is being focused on as the third chain
molecule following nucleic acid and protein. Actually, the post-translational
glycosylation is essential to the viability of eukaryote. The structural
complexity and functional diversity of glycoconjugates attract our scientific
curiosity, and also make it difficult for us to study the glycobiology.
I expect that the chemistry makes large contributions to glycobiology.
Organic synthesis makes it possible for us to produce the carbohydrate
chain we want, and also create brand-new molecules such as probe, marker,
toxin, drug and so on. I want to provide many findings to glycoscience
from the standpoint of a chemist.
- K. Fujikawa, A. Koizumi, M. Hachisu, A. Seko, Y. Takeda, Y. Ito, “Construction of a High-Mannose-Type Glycan
Library by a Renewed Top-Down Chemo-Enzymatic Approach”, Chem. Eur. J., 2015, 21, 3224–3233.
- M. Sakono, A. Seko, Y. Takeda, J. Aikawa, M. Hachisu, A. Koizumi, K. Fujikawa, Y. Ito, “Glycan specificity of a testis-specific lectin chaperone calmegin and effects of hydrophobic interactions”, Biochimica et Biophysica Acta (BBA) - General Subjects, 2014, 1840, 2904–2913.
Takeda, A. Seko, M. Hachisu, S. Daikoku, M. Izumi, A. Koizumi, K.
Fujikawa, Y. Kajihara, Y. Ito, “Both Isoforms of Human UDP-glucose:glycoprotein
Glucosyltransferase are Enzymatically Active”, Glycobiology, 2014, 24 (4), 344-350.
Ohkawa, M. Hachisu, K. Devarayan, J. Araki, “Design and Synthesis of
Peptide-Cellulose Conjugate Molecules –Aspects from Energy/Steric Profiles–”, Fibers Polym., 2013, 14 (12), 1970–1974.
Ohkawa, M. Hachisu, T. Nomura, R. Arai, K. Hirabayashi, M. Tsukada, K.
Abe, “Chain Conformational Study on Underwater Silk Proteins from Caddisfly, Stenopsyche marmorata –Implication of a
Fiber-forming Mechanism–”, Adv. Mater. Res., 2013, 796, 3–8.
A. Koizumi, I. Matsuo, M. Takatani, A. Seko, M. Hachisu, Y.
Takeda, Y. Ito, “Top-down Chemo-enzymatic Approach to High-Mannose-Type Glycan
Library: Synthesis of a Common Precursor and Its Enzymatic Trimming”, Angew. Chem. Int. Ed., 2013, 52 (29), 7426–7431.
Y.Takeda, A. Seko, M. Sakono, M. Hachisu, A. Koizumi, K.
Fujikawa, Y. Ito, “Parallel Quantification of Lectin–Glycan Interaction using
Ultrafiltration”, Carbohydr. Res., 2013, 375, 112–117.
Devarayan, M. Miyamoto, M. Hachisu, J. Araki, V. Periasamy, K. Ohkawa, “Cationic
derivative of electrospun non-woven cellulose-chitosan composite fabrics for
immobilization of aminoacylase-I”, Text.
Res. J., 2013, 83 (18), 1918–1925.
Devarayan, H. Hanaoka, M. Hachisu, J. Araki, M. Ohguchi, B. K. Bijoya, K.
Ohkawa, “Direct Electrospinning of Cellulose-Chitosan Composite Nanofiber”, Macromol. Mater. Eng., 2013, 298 (10), 1059–1064.
Devarayan, T. Hayashi, M. Hachisu, J. Araki, K. Ohkawa, “Correlations
between steric/thermochemical parameters and O-/N-acylation reactions
of cellulose” Carbohydr. Polym., 2013, 94, 468–478.
Devarayan, M. Hachisu, J. Araki, K. Ohkawa, “Synthesis of
peptide-cellulose conjugate mediated by a soluble cellulose derivative having b-Ala esters (II): Conjugates
peptides”, Cellulose, 2013, 20 (1) 365–378.
Ohkawa, M. Nishibayashi, K. Devarayan, M. Hachisu, J. Araki, “Synthesis
of peptide-cellulose conjugate mediated by a soluble cellulose derivative
having b-Ala esters”, Int. J.
Biol. Macromol., 2013, 53, 150–159.
Sakono, A. Seko, Y. Takeda, M. Hachisu, Y. Ito, “Biophysical properties
of UDP-glucose:glycoprotein glucosyltransferase, a folding sensor enzyme in the
ER, delineated by synthetic probes”, Biochem.
Biophys. Res. Commun., 2012, 462 (4), 504–510.
Periasamy, K. Devarayan, M. Hachisu, J. Araki, K. Ohkawa, “Chemical
Modifications of Electrospun Non-woven Hydroxypropyl Cellulose Fabrics for
Immobilization of Aminoacylase-I”, J.
Fiber Bioeng. Inf., 2012, 5 (2), 191–205.
Yamada, I. Nagashima, M. Hachisu, I. Matsuo, H. Shimizu, “Efficient solid-phase synthesis of cyclic RGD
peptides under controlled microwave heating”, TetrahedronLett., 2012, 63 (9), 1066–1070.
- M. Hachisu, H. Hinou, M. Takamichi, S. Tsuda, S-I. Nishimura, “One-pot synthesis
of cyclic antifreeze glycopeptides”, Chem.
Commun., 2009, 1641–1643.
Satoyoshi, M. Hachisu, M. Amaike, K. Ohkawa, H. Yamamoto, “Methionine-Containing
Poly(amino acid) Hybrid Fibers via Self-Assembly at Aqueous Interface”, Macromol. Mater. Eng., 2004, 289 (6), 495–498.
- M. Hachisu, K. Ohkawa, H. Yamamoto, “Preparation of Silk-Like Fibers Designed by
Self-Assembled Ionic Polypeptide”, Macromol.
Biosci., 2003, 3 (2), 92–99.
- Y. Takahashi,
M. Hachisu, K. Ohkawa, H. Yamamoto, “Water-Soluble Polypeptides at
Aqueous Interface Produce Extensible Silk-Like Fiber”, Macromol. RapidCommun., 2002, 23 (9), 540–543.
|･ The Chemical Society of Japan
･ The Society of Polymer Science, Japan
･ Japan Society for Bioscience, Biotechnology, and Agrochemistry
･ The Japanese Society of Carbohydrate Research
･ Forum: Carbohydrates Coming of Age (FCCA)
- ･ Hobbies; Driving a car, Riding a motorcycle
･ E-mail; hachisu[at]riken.jp