YOMO Dynamical Micro-scale Reaction Environment

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Research Director: Tetsuya YOMO<br />
 Professir, Graduate School of Information Science and Technology Osaka University<br />
 Research Term: 2009-2014</p>
<p> Life is frequently defined as an “evolvable and self-sustainable chemical reaction system.” This definition, however, is not widely accepted and represents not all the characteristics of cell, the natural dynamic micro-reactor. The aim of this project is to construct an artificial micro-reactor demonstrating the dynamical properties of natural cells from identified materials. We focus on three dynamic properties: 1) stochasticity, high efficiency, and robustness of internal reactions; 2) recursivity by growth and division; and 3) evolvability by mutation and selection. We compare the constructed artificial micro-reactor with a bacterium, Escherichia coli, to identify the differences and similarities between the artificial and natural dynamic micro-reactors. The construction and comparison will provide a new concept of the “cell” as the minimum unit of life, leading to the design principles for an artificial cell. This project requires interdisciplinary collaboration among various fields such as cell biology, biochemistry, physicochemistry, theoretical biology, and micro- or nanoengineering. This collaboration will cultivate young researchers who will open a new field of science.

Research Director: Tetsuya YOMO
Professir, Graduate School of Information Science and Technology Osaka University
Research Term: 2009-2014

Life is frequently defined as an “evolvable and self-sustainable chemical reaction system.” This definition, however, is not widely accepted and represents not all the characteristics of cell, the natural dynamic micro-reactor. The aim of this project is to construct an artificial micro-reactor demonstrating the dynamical properties of natural cells from identified materials. We focus on three dynamic properties: 1) stochasticity, high efficiency, and robustness of internal reactions; 2) recursivity by growth and division; and 3) evolvability by mutation and selection. We compare the constructed artificial micro-reactor with a bacterium, Escherichia coli, to identify the differences and similarities between the artificial and natural dynamic micro-reactors. The construction and comparison will provide a new concept of the “cell” as the minimum unit of life, leading to the design principles for an artificial cell. This project requires interdisciplinary collaboration among various fields such as cell biology, biochemistry, physicochemistry, theoretical biology, and micro- or nanoengineering. This collaboration will cultivate young researchers who will open a new field of science.

PROJECT OFFICE

Graduate School of Information Science and Technology Osaka University
1-5 Yamadaoka,Suita,Osaka 565-0871. Japan

Research Manager: Yasuaki Kazuta
Administrative Manager: Takeshi Nomoto
Assistant: Mika Okazaki

Phone: +81 (0) 761 51 5800
FAX: +81 (0) 761 51 5889