SATO Live Bio-Forecasting

Project Homepage

Research Director: Thomas N. SATO<br /><br /><br /><br /><br /><br /><br />
 Professor, Nara Institute of Science and Technology (NAIST)<br /><br /><br /><br /><br /><br /><br />
 Director, The Thomas N. Sato BioMEC-X Laboratories, Advanced Telecommunications Research Institute International (ATR)<br /><br /><br /><br /><br /><br /><br />
 Research Term: 2013-2019</p><br /><br /><br /><br /><br /><br />
<p> We propose to realize a novel concept, Live Bio-Forecasting, which is expected to allow us to control by design the future states of the complex, dynamic and stochastic biological processes with unprecedented efficiency and precision.  The “Live Bio-Forecasting” works like weather forecast to predict the future state of physiological processes while the current state is monitored/measured/imaged and simultaneously also to control them by design, all on live (i.e., real-time).  In this project, we will particularly focus on putative alterations of metabolic states of cells of organs conferred by the changes in vascular patterns and functions, which are eventually being manifested as organ functions.  We will decipher molecular and cellular principles and logics underlying such interactions between vascular pattern/function and metabolic state/function of the organ, and will develop predictive computational models, and eventually realize real-time online prediction/forecast of the future states of such processes based on the real-time and quantitative imaging and measurements of their current states.  We will first use developmental and disease models of zebrafish to demonstrate the proof-of-concept of the Live Bio-Forecasting and will form foundation for its future applications to human biology and disease.  We believe the conceptual and technological breakthroughs anticipated from this project will have major and broad impact, not only on biological science, but also on diverse fields of non-biological sciences.  They include, but are not limited to, life science, medicine in particular pre-emptive medicine, robotics engineering, social sciences, meteorological science, geoscience, and information and telecommunications sciences, and our accomplishment is expected to transform our society by delivering unprecedentedly efficient sustainability and long-healthy life style to us.

Research Director: Thomas N. SATO
Director, The Thomas N. Sato BioMEC-X Laboratories, Advanced Telecommunications Research Institute International (ATR)
Research Term: 2013-2018

Human is a multicellular organism consisting of 3.72×1013 cells. Biological activities of each cell are founded by complex chemical reaction such as gene expression and signal transduction. Approximately 109 – 1012 cells make up each organ (e.g., 6×109 and 3.1×1012 cells for the heart and brain, respectively) and cross-talks among multiple organs are critical for the maintenance of homeostasis. Such biological organization establishes the hierarchy which is the basis of complex and non-linear biological systems.
The long-term goal of the project is to decipher mechanisms underlying such multi-scale biological systems. We use experimental animal models such as zebrafish and mouse to unveil how such hierarchical organization is established during development and maintained in adult. We also investigate the early triggers leading to the dysfunction of such systems that ultimately results in various disease conditions. To validate findings with these animal models, we also conduct clinical research with human subjects. To facilitate defining and solving non-linear and complex problems associated with the study of multi-scale biological systems, we take advantages of concepts and tools of mathematical modeling, computational science and engineering, as necessary.
Our studies are expected to contribute to the development of more efficient and effective diagnostic and therapeutic methods, such as “Live Bio-Forecasting System” or “Virtual Live Clinics” where the measurements of the current conditions and forecasting and controlling/pre-empting the future conditions are all accomplished in real-time. The aims of the project are to make critical conceptual and technical breakthroughs leading such technological innovation.


Project Headquarter

Advanced Telecommunications Research Institute International
2-2-2 Hikaridai Seika-cho, Soraku-gun, Kyoto 619-0288, JAPAN

Research Coordinator:Shinpei KAWAOKA
Research Manager:Toshiya MORIE
Administrative Manager:Ryoko TAKAHASHI
Administrative Staff:Erika KOJIMA