MURATA Lipid Active Structure

Project Homepage

Research Director: Michio MURATA<br />
 Professor, Department of Chemistry, Graduate School of Science, Osaka University<br />
 Research Term: 2010-2015</p>
<p> Lipids are a main component of the biomembranes. Recently, membrane lipids have been shown to play key roles in cell physiology through interactions with proteins. On the other hand, structural biology, which has greatly accelerated the advance of biosciences, focuses largely on proteins and deals little with lipids and lipid ligands. Since lipids are highly flexible molecules, elucidation of their 3D structures upon binding to a receptor is extremely difficult even with X-ray crystallography.<br />
   In this project, we will elucidate the active structure of lipids in and around proteins by means of solid-state NMR techniques combined with X-ray crystallography, organic synthesis and protein engineering. Function of lipids will be more profoundly understood in terms of their 3D structures. This breakthrough will advance our knowledge in biological and biomedical sciences over the next decade, thus eventually stimulating research and development in medical and pharmaceutical areas.

Research Director: Michio MURATA
Professor, Department of Chemistry, Graduate School of Science, Osaka University
Research Term: 2010-2015

Lipids are a main component of the biomembranes. Recently, membrane lipids have been shown to play key roles in cell physiology through interactions with proteins. On the other hand, structural biology, which has greatly accelerated the advance of biosciences, focuses largely on proteins and deals little with lipids and lipid ligands. Since lipids are highly flexible molecules, elucidation of their 3D structures upon binding to a receptor is extremely difficult even with X-ray crystallography.
In this project, we will elucidate the active structure of lipids in and around proteins by means of solid-state NMR techniques combined with X-ray crystallography, organic synthesis and protein engineering. Function of lipids will be more profoundly understood in terms of their 3D structures. This breakthrough will advance our knowledge in biological and biomedical sciences over the next decade, thus eventually stimulating research and development in medical and pharmaceutical areas.

Project Headquarter

1-1 Machikaneyama, Toyonaka, Osaka 560-0043, Japan 

Project Coordinator; Shigeru Matsuoka
Research Manager; Fuminori Sato
Administrative Manager; Keiichi Matsumoto
Administrative Staff; Saori Ichino

Phone: +81 (0) 6 6850 5575
FAX: +81 (0)  6 6850 5573 
E-mail: matsumoto-k office.osaka-u.ac.jp