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KAWAOKA Infection-induced Host Responses

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Research Director: Yoshihiro KAWAOKA<br />
Professor, Division of Virology, Institute of Medical Science University of Tokyo <br />
Research Term: 2008-2013<br />
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Viral infections have a tremendous impact on human health, yet little is known about the interactions between the pathogen and its host. We, therefore, propose a Systems Biology Approach to analyze virus infections in different biological systems, identify pathogen-host interactions, characterize host cell responses, and correlate these data with bioinformatics approaches. Influenza viruses are an ideal model system due to their impact on human health and the global economy. A eVirology/Cell Biology Unitf will characterize influenza viral replication and pathogenicity in cells and animals and identify host-virus interaction partners. A eHost Cell Response Unitf will study the cellular transcriptome in response to viral infection. Data analysis and modeling of cellular responses will be conducted by the eComputational Systems Biology Unitf. These studies will lead to a comprehensive understanding of the cellular networks activated upon viral infections and are, therefore, expected to establish new concepts in study of viral diseases.

Research Director: Yoshihiro KAWAOKA
Professor, Division of Virology, Institute of Medical Science University of Tokyo
Research Term: 2008-2013

Viral infections have a tremendous impact on human health, yet little is known about the interactions between the pathogen and its host. We, therefore, propose a Systems Biology Approach to analyze virus infections in different biological systems, identify pathogen-host interactions, characterize host cell responses, and correlate these data with bioinformatics approaches. Influenza viruses are an ideal model system due to their impact on human health and the global economy. A eVirology/Cell Biology Unitf will characterize influenza viral replication and pathogenicity in cells and animals and identify host-virus interaction partners. A eHost Cell Response Unitf will study the cellular transcriptome in response to viral infection. Data analysis and modeling of cellular responses will be conducted by the eComputational Systems Biology Unitf. These studies will lead to a comprehensive understanding of the cellular networks activated upon viral infections and are, therefore, expected to establish new concepts in study of viral diseases.

PROJECT OFFICE

4F, Second Bldg., The Institute of Medical Science, The University of Tokyo
4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, JAPAN

Research Manager: Tetsuzo Fukuda
Administrative Manager: Masao Miyakawa
Assistant: Kazumi Takamizawa

Phone: +81 (0) 3 6459 3261
FAX: +81 (0) 3 6459 3273