HIGASHIYAMA Live-Holonics

Project Homepage

Research Director: Tetsuya HIGASHIYAMA<br />
 Professor of Graduate School of Science, Nagoya University<br />
 Research Term: 2010-2015</p>
<p> Individual cells of multicellular organisms communicate with neighboring cells to maintain the organism. Each cell in a multicellular organism learns its role in the cell population through dynamic and intricate communication with surrounding and distant cells. We call this cell-to-cell communication as "holonic communication". However, it is still unclear how cells actually communicate with each other in a living organism.<br />
  The goal of this project is to understand holonic communication in a living, multicellular organism. For this purpose, our project sets up three research groups for optical technology, engineering technology, and single-cell omics to make a new frontier in 'live cell biology' ― the real-time analysis of intercellular signaling in multicellular organisms.<br />
  For live-cell analyses with complete control under the microscope, various new technologies are expected to be developed such as live-cell and single-molecule imaging, manipulation techniques for cell and molecules, interdisciplinary studies of plant biology and engineering technologies, and nano- and micro-device engineering. These technologies will be applicable to other fields, not only scientific instruments but also diagnosis methods for medical care, reproductive medicine, and breeding techniques for agriculture.

Research Director: Tetsuya HIGASHIYAMA
Professor of Graduate School of Science, Nagoya University
Research Term: 2010-2015

Individual cells of multicellular organisms communicate with neighboring cells to maintain the organism. Each cell in a multicellular organism learns its role in the cell population through dynamic and intricate communication with surrounding and distant cells. We call this cell-to-cell communication as "holonic communication". However, it is still unclear how cells actually communicate with each other in a living organism.
 The goal of this project is to understand holonic communication in a living, multicellular organism. For this purpose, our project sets up three research groups for optical technology, engineering technology, and single-cell omics to make a new frontier in ‘live cell biology’ ― the real-time analysis of intercellular signaling in multicellular organisms.
 For live-cell analyses with complete control under the microscope, various new technologies are expected to be developed such as live-cell and single-molecule imaging, manipulation techniques for cell and molecules, interdisciplinary studies of plant biology and engineering technologies, and nano- and micro-device engineering. These technologies will be applicable to other fields, not only scientific instruments but also diagnosis methods for medical care, reproductive medicine, and breeding techniques for agriculture.

Project Headquarter

B-103, Bldg. B, Graduate School of Science, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8602, JAPAN

Research Manager/Project Coordinator;  Yoko Hattori
Administrative Manager;  Yoshiki Tsuji
Administrative Staff;  Mikiko Fukatsu

Phone: +81 (0) 52 789 2496
FAX:+81 (0) 52 789 2497 
E-mail: hattori.yoko f.mbox.nagoya-u.ac.jp