AKIYOSHI Bio-Nanotransporter

Project Homepage

akiyoshi_portrait

Research Director: Kazunari AKIYOSHI
Professor, Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University
Research Term: Oct 2011 - Mar 2017
Special Extention Period: Apr 2017 - Mar 2018
Grant Number: JPMJER1101

 

The biologics including proteins, nucleic acids and extracellular vesicles (exosomes) have been attracted attention as innovative pharmaceutical products in advanced nanomedicine. In this project, new bio-nanotransporters (bio-inspired nanoparticles) have been developed for new drug delivery systems(DDS) especially for such biologics to apply cancer immuno-therapies, vaccines and tissue engineering. We proposed nanogel tectonics using self-assembled nanogels as building blocks to construct multi functional well-controlled gel biomaterials, e.g. artificial cellular matrix and tissue scaffold. Proteoliposomes were efficiently prepared by cell-free membrane protein synthesis with liposome chaperone (artificial cell method) for bio-analysis and DDS. New strategy for functionalization of exosomes has been developed by fusion with nanogel engineering and liposome engineering. Functions of T cell derived exosomes for cancer microenvironment were newly found and the exosomes can be applied to new cancer immunotherapy.

 

akiyoshi_fig

Quick Access

Quick Access

Program

Program
  • CREST
  • PRESTO
  • ACT-I
  • ERATO
  • ACT-C
  • ACCEL
  • ALCA
  • RISTEX
Finish programs
  • Pamphlet
  • ProjectDatabase
  • GlobalActivities
  • Diversity
  • OpenSciencePolicy
  • InquiryForm