We have succeeded in the development of incubation type ionchannel biosensor, which can measure precisely the ionchannel currents passing through the post synaptic membrane. In this research, we are going to form the neural network in the ionchannel biosensor and measure the memory and learning function of the network by inducing the action potential using laser irradiations. Furthermore, we are going to make the device multichannel type by using the top level nanofabrication technique, and develop the high through put screening device, which is useful for the analysis and drag discovery with the neurodegenerative diseases and also for unveiling of the higher order function of brain.

The extended nano, 10¹-10³ nm space is a unique space composed of only interfacial field. Our research group has found that unique properties appear on fluid characteristics and chemistry there, and demonstrated that those properties could open new horizon of micro/nano science and technology. This research aims to create novel device engineering exploiting the unique properties of the extended nano space, and realize new functional nano devices contributing to chemical, biological and energy fields.

By combination of damage-free neutral beam etching and dense spherical bio-molecule template, we will develop super-high efficiency quantum-dot laser and quantum-dot solar cell. Additionally, through studying the carrier transport in the 2-dimensional array of silicon and compound semiconductor, we will prove the quantum dot size effect, miniband formation, and multiple exiton generation and then establish the method to control the quantum structure.

By improving substantially the controllability of molecular self-assembly and printing, I and my research team will establish a new scheme, which we refer to as "nanoprinting", to introduce nanofunctions in meter-scale large-area systems. And thus by integrating various nanofunctions on a plastic film, we will realize a novel sheet-type nano-system. This is a research challenge to show its feasibility as a machine interface that assists people by covering the surfaces of objects-ideally.

We succeeded in preparing a new type of polymer assemblies, a concentrated polymer brush, with novel structure and properties. This project aims at fabricating new/novel nanosystems by hierarchically assembling such brush structure and then at developing new devices such as a all-solid lithium-ion microbattery and a non-invasive/wearable sensor monitoring tear glucose.

A system to showcase the behaviors of cells and tissues is realized by introducing artificial bio-surfaces into a microfluidic device. The microenvironment surrounding the cells and tissues, which is defined by the conditions of solutions and contacting surfaces, is controlled in an integrative way in the system. The system will be applied to the studies on the effect of microenvironments on the processes of differentiation of ES and iPS cells, leading to the realization of micro-nano integrated devices relevant to such scientific and diagnostic or therapeutic purposes.