Research Theme

Mechanisms of lysosomal secretion by inflammatory macrophages

Macrophages play central roles in the development of inflammation. During inflammation, macrophages engulf apoptotic cells and/or bacteria, and digest them in lysosomes. However, undigested debris in lysosomes can be released from macrophages with lysosomal enzymes. The secreted lysosomal enzymes can be noxious to the surrunding tissues, and may cause chronic inflammation. In this study, we will reveal the molecular mechanisms underlying lysosomal secretion by macrophages and unravel its relevance to the development of chronic inflammation.

Research Results