Researchers
Takayuki Kuraishi – The elucidation of evolutionarily conserved mechanisms that activate innate immune system by "intrinsic ligands"
Researcher
- Takayuki Kuraishi
- Associate professor, Laboratory of Host Defense and Responses, Graduate School of Medical Sciences, Kanazawa University
Research Theme
The elucidation of evolutionarily conserved mechanisms that activate innate immune system by "intrinsic ligands"
Chronic inflammation is considered to be a basis for lifestyle related diseases, such as cancer and obesity. NF-κB is a major regulator of chronic inflammation, and thus we have investigated the mechanisms of NF-κB activation. We previously have found that a novel signaling pathway that activates NF-κB in Drosophila and mammalian cells. In this study, we are seeking to identify all components of this pathway to find new factors that regulate chronic inflammation, hopefully leading to a discovery of clinical targets for lifestyle related diseases.
