Reserach

Researchers

PRESTOCREST
  • FY 2010
  • FY 2011
  • FY 2012

  • Motoyuki OTSUKA
  • Hiroki KATO
  • Takayuki KURAISHI
  • Ai KOTANI
  • Takashi SAITO
  • Mitoaki SANO
  • Takayoshi SUGANAMI
  • Takahisa NAKAMURA
  • Rikinari HANAYAMA
  • Reo MARUYAMA

Hiroki Kato – Investigation of lupus-like chronic nephritis in a mouse model

Researcher

Hiroki Kato
Associate Professor, Institute for Virus Research, Kyoto University
http://www.virus.kyoto-u.ac.jp/Lab/bunshiiden2012/English/index.html
Research Theme
Investigation of lupus-like chronic nephritis in a mouse model

Chronic inflammation causes various illnesses, such as an autoimmune disease; however, the mechanism remains to be clarified. Recently we have obtained the mouse which has point mutation in a virus sensor molecule MDA5 and develops lupus-like nephritis. Utilizing this mouse model, chronic inflammation caused by the defect of innate immune system and involvement of viral infection in this inflammation are investigated. We aim at the elucidation of pathomechanisms in the development of nephritis and also at new establishment of the prevention and treatment for human lupus nephritis.

Research Results
The 5 Cardinal Signs of Inflammation