Reserach

Researchers

PRESTOCREST
  • FY 2010
  • FY 2011
  • FY 2012

  • Koji AOKI
  • Kenichi ASANO
  • Koji ATARASHI
  • Takaharu OKADA
  • Junko SASAKI
  • Katsuaki SATO
  • Takashi SHICHITA
  • Kazuhiro SUZUKI
  • Takashi TANAKA
  • Susumu NAKAE
  • Sachie HIRATSUKA
  • Kumiko MAKIDE
  • Tohru MINAMINO
  • Tadashi YOKOSUKA

Tadashi Yokosuka – Molecular imaging of MAPK pathway for sustained T cell activation

Researcher

Tadashi Yokosuka
Professor, Department of Immunology, Tokyo Medical University
Research Theme
Molecular imaging of MAPK pathway for sustained T cell activation

MAPK pathway contributes to the entire process from the outside recognition to the transcription in a various type of cells. Its disruption is seriously related to the pathogenesis and the clinical states of inflammatory diseases. To elucidate the mechanisms of the T cell-mediated chronic inflammation, I will examine the functions of the TCR microcluster, a minimal activation unit of TCR signaling, in the MAPK pathway and comprehensively understand this pathway from the view of molecular imaging.

Research Results
The 5 Cardinal Signs of Inflammation