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Researchers

PRESTOCREST
  • FY 2010
  • FY 2011
  • FY 2012

  • Makoto ARITA
  • Tatsushi IGAKI
  • Naoko OHTANI
  • Masatsugu OH-HORA
  • Shinobu SAIJO
  • Tomohiro SAWA
  • Yuki SUGIURA
  • Kohsuke TAKEDA
  • Norihiko TAKEDA
  • Yasushi HIROTA
  • Kazuyo MORO
  • Masakatsu YAMASHITA
  • Hiroshi WATARAI

Masakatsu Yamashita – Control of the mechanisms underlying chronic inflammation through epigenetic modulation of T cell memory

Researcher

Masakatsu Yamashita
Professor, Ehime University Graduate School of Medicine, Department of Immunology
Research Theme
Control of the mechanisms underlying chronic inflammation through epigenetic modulation of T cell memory

Inflammation is a primary defense process against various extracellular stimuli, such as pathogens, and environmental stresses. However, a state of chronic inflammation occurs, if the stimulation is sustained. Development of chronic inflammation is closely associated with the aberrant induction of T cell memory. Thus, we are examining functional roles of T cell memory in the development of chronic inflammation using epigenectic procedures. The goal of this study is to propose a novel therapeutic approach and a molecular basis for pharmacoepigenomics in chronic inflammation through epigenetic modulation of T cell memory.

Research Results
The 5 Cardinal Signs of Inflammation