Home Principle Investigators, Research Themes (FY2010)
Akira SHIBUYA | Control of allergic diseases by regulation of human mast cell activation |
Kiyoshi TAKEDA | Development of a new strategy targeting innate immunity for treatment of intestinal immune disorders |
Control of allergic diseases by regulation of human mast cell activation
Researcher's name | Akira SHIBUYA |
Research Site | University of Tsukuba Professor |
URL | http://en.immunologylab-tsukuba.org/ |
Content | Allergy is induced by the release of chemical mediators from mast cells. We identified novel immunoreceptors, Allergin-1 and MAIR-I, which inhibit the release of chemical mediators from mast cells. In this project, we will search novel inhibitory immunoreceptors expressed on human mast cells and clarify their role in the regulatory mechanism of allergic diseases. Furthermore, we will develop novel therapeutic approach targetting the inhibitory immunoreceptors on mast cells for allergic diseases. |
Development of a new strategy targeting innate immunity for treatment of intestinal immune disorders
Researcher's name | Kiyoshi TAKEDA |
Research Site | Osaka University Professor |
URL | http://www.med.osaka-u.ac.jp/pub/ongene/index.html |
Content | Disregulated activity of innate immunity causes several immune disorders such as inflammatory bowel diseases. Mucosal immunity is an unique system, and there exist peculiar subsets of innate immune cells, which regulate intestinal homeostasis. In this project, we will reveal the regulatory mechanism for mucosal immune responses by innate immunity, and will develop a new strategy to treat intestinal immune disorders. |