Home → Principle Investigators, Research Themes (FY2010)

Principle Investigators, Research Themes

Akira SHIBUYA Control of allergic diseases by regulation of human mast cell activation
Kiyoshi TAKEDA Development of a new strategy targeting innate immunity for treatment of intestinal immune disorders

Control of allergic diseases by regulation of human mast cell activation

Researcher's name Akira SHIBUYA
Research Site University of Tsukuba Professor
URL http://en.immunologylab-tsukuba.org/
Content Allergy is induced by the release of chemical mediators from mast cells. We identified novel immunoreceptors, Allergin-1 and MAIR-I, which inhibit the release of chemical mediators from mast cells. In this project, we will search novel inhibitory immunoreceptors expressed on human mast cells and clarify their role in the regulatory mechanism of allergic diseases. Furthermore, we will develop novel therapeutic approach targetting the inhibitory immunoreceptors on mast cells for allergic diseases.
Control of allergic diseases by regulation of human mast cell activation

Development of a new strategy targeting innate immunity for treatment of intestinal immune disorders

Researcher's name Kiyoshi TAKEDA
Research Site Osaka University Professor
URL http://www.med.osaka-u.ac.jp/pub/ongene/index.html
Content Disregulated activity of innate immunity causes several immune disorders such as inflammatory bowel diseases. Mucosal immunity is an unique system, and there exist peculiar subsets of innate immune cells, which regulate intestinal homeostasis. In this project, we will reveal the regulatory mechanism for mucosal immune responses by innate immunity, and will develop a new strategy to treat intestinal immune disorders.
Development of a new strategy targeting innate immunity for treatment of intestinal immune disorders