研究報告と成果
平成23年度採択研究課題の研究業績（平成２４年度まで）
鍋倉チーム
Kim SK, Kato G, Ishikawa T, Nabekura J (2011) Phase-specific plasticity of the synaptic structures in the somatosensory cortex of living mice during neuropathic pain. Mol Pain 7:87. (DOI:10.1186/1744-8069-7-87)
Suyama S, Sunabori T, Kanki H, Sawamoto K, Gachet C, Koizumi S, Okano H (2012) Purinergic Signaling Promotes Proliferation of Adult Mouse Subventricular Zone Cells. J Neurosci 32:9238-9247. (DOI:10.1523/JNEUROSCI.4001-11.2012)
Morizawa Y, Sato, K, Takaki J, Kawasaki A, Shibata K, Suzuki T, Ohta S, Koizumi S (2012) Cell-autonomous Enhancement of Glutamate-uptake by Female Astrocytes. Mol Cell Neurobiol 32:953-956. (DOI:10.1007/s10571-012-9829-z)
Eto K, Ishibashi H, Yoshimura T, Watanabe M, Miyamoto A, Ikenaka K, Moorhouse AJ, Nabekura J (2012) Enhanced GABAergic Activity in the Mouse Primary Somatosensory Cortex Is Insufficient to Alleviate Chronic Pain Behavior with Reduced Expression of Neuronal Potassium-Chloride Cotransporter. J Neurosci 32:16552-16559. (DOI:10.1523/JNEUROSCI.2104-12.2012)
Wake H, Moorhouse AJ, Miyamoto A, Nabekura J (2013) Microglia: Actively Surveying and Shaping Neuronal Circuit Structure and Function. Trends Neurosci 36:209-217. (DOI:10.1016/j.tins.2012.11.007)
Kinoshita M, Nasu-Tada K, Fujishita K, Sato K, Koizumi S (2013) Secretion of Matrix Metalloproteinase-9 from Sstrocytes by Inhibition of Tonic P2Y(14)-receptor-Mediated Signal(s). Cell Mol Neurobiol 33:47-58. (DOI:10.1007/s10571-012-9869-4)
Ishibashi H, Witt MR, Nabekura J, Nielsen M (2013) Modulation of Diazepam-insensitive GABA(A) Receptors by Micromolar Concentrations of Thyroxine and Related Compounds in vitro. Brain Res 1490:1-8. (DOI:10.1016/j.brainres.2012.10.038)
Beppu K, Kosai Y, Kido MA, Akimoto N, Mori YY, Kojima Y, Fujita K, Okuno Y, Yamakawa Y, Ifuku M, Shinagawa R, Nabekura J, Sprengel R, Noda M (2013) Expression, Subunit Composition and Function of AMPA-type Glutamate Receptors are Changed in Activated Microglia: Possible Contribution of GluA2 (GluR-B)-Deficiency under Pathological Conditions. Glia (in press) (DOI:10.1002/glia.22481)
Takatsuru Y. Eto K, Kaneko R, Masuda H, Shimokawa N, Koibuchi N, Nabekura J (2013) Critical Role of the Astrocyte for Functional Remodeling in Contralateral Hemisphere of Somatosensory Cortex after Stroke. J Neurosci 33:4683-4692. (DOI:10.1523/JNEUROSCI.2657-12.2013)
Noguchi Y, Shinozaki Y, Fujishita K, Shibata K, Imura Y, Morizawa Y, Gachet C, Koizumi S (2013) Astrocytes Protect Neurons against Methylmercury via ATP/P2Y1 Receptor-mediated Pathways in Astrocytes. PLoS One （in press）.
Imura Y, Morizawa Y, Komatus R, Shibata K, Shinozaki Y, Moriyama Y, Koizumi S (2013) Microglia release ATP by Exocytosis. Glia (in press).
星チーム
Inoue K, Koketsu D, Kato S, Kobayashi K, Nambu A, Takada M (2012) Immunotoxin-mediated tract targeting in the primate brain: selective elimination of the cortico-subthalamic "hyperdirect" pathway. PLoS ONE 7:e39149. (DOI:10.1371/journal.pone.0039149)
Takahara D, Inoue KI, Hirata Y, Miyachi S, Nambu A, Takada M, Hoshi E (2012) Multisynaptic projections from the ventrolateral prefrontal cortex to the dorsal premotor cortex in macaques - anatomical substrate for conditional visuomotor behavior. Eur J Neurosci 36:3365-3375. (DOI:10.1111/j.1460-9568.2012.08251.x)
Yamagata T, Nakayama Y, Tanji J, Hoshi E (2012) Distinct information representation and processing for goal-directed behavior in the dorsolateral and ventrolateral prefrontal cortex and the dorsal premotor cortex. J Neurosci 32:12934-12949. (DOI:10.1523/JNEUROSCI.2398-12.2012)
→東京都医学総合研究所よりプレス発表
Hirata Y, Miyachi S, Inoue KI, Ninomiya T, Takahara D, Hoshi E, Takada M (2012) Dorsal Area 46 Is a Major Target of Disynaptic Projections From the Medial Temporal Lobe. Cereb Cortex Sep 17. [Epub ahead of print] (DOI:10.1093/cercor/bhs286)
Nishizawa K, Fukabori R, Okada K, Kai N, Uchigashima M, Watanabe M, Shiota A, Ueda M, Tsutsui Y, Kobayashi K (2012) Striatal indirect pathway contributes to selection accuracy of learned motor actions. J Neurosci 32:13421-32. (DOI:10.1523/JNEUROSCI.1969-12.2012)
Lu X, Miyachi S, Takada M (2012) Anatomical evidence for the involvement of medial cerebellar output from the interpositus nuclei in cognitive functions. Proc Natl Acad Sci U S A 109:18980-4. (DOI:10.1073/pnas.1211168109)
Chiken S, Nambu A (2013) High-frequency pallidal stimulation disrupts information flow through the pallidum by GABAergic inhibition. J Neurosci 33:2268-80. (DOI:10.1523/JNEUROSCI.4144-11.2013)
Sano H, Chiken S, Hikida T, Kobayashi K, Nambu A (2013) Signals through the striatopallidal indirect pathway stop movements by phasic excitation in the substantia nigra. J Neurosci (in press)
宮下チーム
Adachi Y, Osada T, Sporns O, Watanabe T, Matsui T, Miyamoto K, Miyashita Y (2012) Functional Connectivity between Anatomically Unconnected Areas Is Shaped by Collective Network-level Effects in the Macaque Cortex. Cereb Cortex 22:1586-1592. (DOI:10.1093/cercor/bhr234)
Tsubota T, Ohashi Y, Tamura K, Miyashita Y (2012) Optogenetic inhibition of Purkinje cell activity reveals cerebellar control of blood pressure during postural alterations in anesthetized rats. Neuroscience 210:137-144. (DOI:10.1016/j.neuroscience.2012.03.014)
Hirose S, Watanabe T, Jimura K, Katsura M, Kunimatsu A, Abe O, Ohtomo K, Miyashita Y, Konishi S (2012) Local Signal Time-Series during Rest Used for Areal Boundary Mapping in Individual Human Brains. PLoS One 7:e36496. (DOI:10.1371/journal.pone.0036496)
Watanabe T, Kimura HM, Hirose S, Wada H, Imai Y, Machida T, Shirouzu I, Miyashita Y, Konishi K (2012) Functional Dissociation between Anterior and Posterior Temporal Cortical Regions during Retrieval of Remote Memory. J Neurosci 32:9659-9670. (DOI:10.1523/JNEUROSCI.5553-11.2012)
Watanabe T, Yahata N, Abe O, Kuwabara H, Inoue H, Takano Y, Iwashiro N, Natsubori T, Aoki Y, Takao H, Sasaki H, Gonoi W, Murakami M, Katsura M, Kunimatsu A, Kawakubo Y, Matsuzaki H, Tsuchiya KJ, Kato N, Kano Y, Miyashita Y, Kasai K, Yamasue H (2012) Diminished medial prefrontal activity behind autistic social judgments of incongruent information. PLoS One 7:e39561. (DOI:10.1371/journal.pone.0039561)
Hirose S, Chikazoe J, Watanabe T, Jimura K, Kunimatsu A, Abe O, Ohtomo K, Miyashita Y, Konishi S (2012) Efficiency of Go/No-Go Task Performance Implemented in the Left Hemisphere. J Neurosci 32:9059-9065. (DOI:10.1523/JNEUROSCI.0540-12.2012)
Iwai L, Ohashi Y, van der List D, Usrey WM, Miyashita Y, Kawasaki H (2012) FoxP2 is a parvocellular-specific transcription factor in the visual thalamus of monkeys and ferrets. Cereb Cortex Jul 12. [Epub ahead of print] (DOI:10.1093/cercor/bhs207)
Miyamoto K, Hirabayashi T, Miyashita Y (2012) To bet, or not to bet: that is the question of SEF spikes. Neuron 75:358-360 (DOI:10.1016/j.neuron.2012.07.012)
Hirose S, Watanabe T, Wada H, Imai Y, Machida T, Shirouzu I, Miyashita Y, Konishi S (2012) Functional Relevance of Micro-Modules in Human Association Cortex Delineated with High-Resolution fMRI. Cereb Cortex Aug 31[Epub ahead of print] (DOI:10.1093/cercor/bhs268)
Kamigaki T, Fukushima T, Tamura K, Miyashita Y (2012) Neurodynamics of Cognitive Set Shifting in Monkey Frontal Cortex and Its Causal Impact on Behavioral Flexibility. J Cogn Neurosci 24:2171-2185. (DOI:10.1162/jocn_a_00277)
Tamura K, Ohashi Y, Tsubota T, Takeuchi D, Hirabayashi T, Yaguchi M, Matsuyama M, Sekine T, Miyashita Y (2012) A glass-coated tungsten microelectrode enclosing optical fibers for optogenetic exploration in primate deep brain structures. J Neurosci Methods 211:49-57. (DOI:10.1016/j.jneumeth.2012.08.004)
Matsui T, Koyano KW, Tamura K, Osada T, Adachi Y, Miyamoto K, Chikazoe J, Kamigaki K, Miyashita Y (2012) fMRI activity in the macaque cerebellum evoked by intracortical microstimulation of the primary somatosensory cortex: evidence for polysynaptic propagation. PLoS ONE 7:e47515. (DOI:10.1371/journal.pone.0047515)
Hirabayashi T, Takeuchi D, Tamura K, Miyashita Y (2013) Functional micro-circuit recruited during retrieval of object association memory in monkey perirhinal cortex. Neuron 77:192-203. (DOI:10.1016/j.neuron.2012.10.031)
→東京大学との共同発表
Watanabe T, Hirose S, Wada H, Imai Y, Machida T, Shirouzu I, Konishi S, Miyashita Y, Masuda N (2013) A pairwise maximum entropy model accurately describes resting-state human brain networks. Nat Commun 4:1370. (DOI:10.1038/ncomms2388)
Miyamoto K, Osada T, Adachi Y, Matsui T, Kimura HM, Miyashita Y (2013) Functional differentiation of memory retrieval network in macaque posterior parietal cortex. Neuron 77:787-799. (DOI:10.1016/j.neuron.2012.12.019)
八木チーム
Yagi T（2012) Molecular codes for neuronal individuality and cell assembly in the brain. Front Mol Neurosci 5:45. (DOI:10.3389/fnmol.2012.00045)
Yamashita H, Shanlin C, Komagata S, Hishida R, Iwasato T, Itohara S, Yagi T, Endo N, Shibata M, Shibuki K（2012) Restoration of contralateral representation in the mouse somatosensory cortex after crossing nerve transfer. PLoS One 7:e35676. (DOI:10.1371/journal.pone.0035676)
Hirayama T, Tarusawa E, Yoshimura Y, Galjart N, Yagi T （2012） CTCF is required for neural development and stochastic expression of clustered Pcdh genes in neurons. Cell Reports 2:345-357. (DOI:10.1016/j.celrep.2012.06.014)
→大阪大学よりプレス発表
Hirano K, Kaneko R, Izawa T, Kawaguchi M, Kitsukawa, Yagi T （2012) Single-neuron diversity generated by Protocadherin-β cluster in mouse central and peripheral nervous systems. Front Mol Neurosci 5:90. (DOI:10.3389/fnmol.2012.00090)
Hasegawa S, Hirabayashi T, Kondo T, Inoue K, Esumi S, Okayama A, Hamada S, Yagi T （2012) Constitutively expressed Protocadherin-a regulates the coalescence and elimination of homotypic olfactory axons through its cytoplasmic region. Front Mol Neurosci 5:97. (DOI:10.3389/fnmol.2012.00097)
Hirayama T, Yagi T（2013) Clustered Protocadherins and Neuronal Diversity. Prog Mol Biol Transl Sci. 116:145-167. (DOI:10.1016/B978-0-12-394311-8.00007-8)