研究報告と成果
平成22年度採択研究課題の研究業績（平成２４年度まで）
伊藤チーム
Shinomiya K, Matsuda K, Oishi T, Otsuna H, Ito, K (2011) Flybrain neuron database: a comprehensive database system of the Drosophila brain neurons. J Comp Neurol 519:807-833. (DOI:10.1002/cne.22540)
Das S, Sadanandappa MK, Dervan A, Larkin A, Lee JA, Sudhakaran IP, Priya R, Heidari R, Holohan EE, Pimentel A, Gandhi A, Ito K, Sanyal S, Wang JW, Rodrigues V, Ramaswami M (2011) Plasticity of local GABAergic interneurons drives olfactory habituation. Proc Natl Acad Sci USA 108:E646-654. (DOI:10.1073/pnas.1106411108)
Sejourne J, Placais PY, Aso Y, Siwanowicz I, Trannoy S, Thoma V, Tedjakumala SR, Rubin GM, Tchenio P, Ito K, Isabel G, Tanimoto H, Preat T (2011) Mushroom body efferent neurons responsible for aversive olfactory memory retrieval in Drosophila. Nat Neurosci 14:903-910. (DOI:10.1038/nn.2846)
Endo K, Karim MR, Taniguchi H, Krejci A, Kinameri E, Siebert M, Ito K, Bray SJ, Moore AW (2012) Chromatin modification of Notch targets in olfactory receptor neuron diversification. Nat Neurosci 15:224-233. (DOI:10.1038/nn.2998)
Mu L, Ito K, Bacon JP, Strausfeld NJ(2012) Optic glomeruli and their inputs in Drosophila share an organizational ground pattern with the antennal lobes. J Neurosci 32:6061-71.(DOI:10.1523/JNEUROSCI.0221-12.2012)
Aso Y, Herb A, Ogueta M, Siwanowicz I, Templier T, Friedrich AB, Ito K, Scholz H, Tanimoto H (2012) Three dopamine pathways induce aversive odor memories with different stability. PLoS genetics 8:e1002768. (DOI:10.1371/journal.pgen.1002768)
Ueno T, Tomita J, Tanimoto H, Endo K, Ito K, Kume S, Kume K (2012) Identification of a dopamine pathway that regulates sleep and arousal in Drosophila. Nat Neurosci 15:1516-1523. (DOI:10.1038/nn.3238)
Tanaka NK, Endo K, Ito K (2012) The organization of antennal lobe-associated neurons in the adult Drosophila melanogaster brain. J Comp Neurol 520:4067-4130. (DOI:10.1002/cne.23142)
Ito M, Masuda N, Shinomiya K, Endo K, Ito, K (2013) Systematic analysis of neural projections reveals clonal composition of the Drosophila brain. Curr Biol, in press
→東京大学よりプレス発表
大木チーム
Ohtsuki G, Nishiyama M, Yoshida T, Murakami T, Histed M, Lois C, Ohki K (2012) Similarity of visual selectivity among clonally related neurons in visual cortex. Neuron 75:65-72. (DOI:10.1016/j.neuron.2012.05.023)
→九州大学との共同発表
Hayashi Y, Tagawa Y, Yawata S, Nakanishi S, Funabiki K (2012) Spatio-temporal control of neural activity in vivo using fluorescence microendoscopy. Eur J Neurosci 36:2722-2732. (DOI:10.1111/j.1460-9568.2012.08181.x)
Hagihara KM, Ohki K (2013) Long-term down-regulation of GABA decreases orientation selectivity without affecting direction selectivity in mouse primary visual cortex. Front Neural Circuits 7:1-11. (DOI:10.3389/fncir.2013.00028)
Bando Y, Hirano T, Tagawa Y. (2012) Dysfunction of KCNK potassium channels impairs neuronal migration in the developing mouse cerebral cortex. Cerebral Cortex, bhs387. (in press)
酒井チーム
Muragaki Y, Iseki H, Maruyama T, Tanaka M, Shinohara C, Suzuki T, Yoshimitsu K, Ikuta S, Hayashi M, Chernov M, Hori T, Okada Y, Takakura K (2011) Information-guided surgical management of gliomas using low-field-strength intraoperative MRI. Acta Neurochir Suppl 109:67-72.(DOI:10.1007/978-3-211-99651-5_11)
Fukui N (2011) Merge and Bare Phrase Structure. The Oxford Handbook of Linguistic Minimalism, ed. Cedric Boeckx, 73-95. Oxford: Oxford University Press. (DOI:10.1093/oxfordhb/9780199549368.013.0004)
久野正和 (2010)「否定一致表現の構成要素と認可の方略」『否定と言語理論』,加藤泰彦,吉村あき子,今仁生美（編）97-117, 開拓社.
Zushi M (2011) The Syntax of Dative Constructions in Japanese. Jinbun Kenkyuu 173:1-51.
田村学、上松右二、板倉徹、西林宏起、小倉光博、JF-Mangin、J-Regis、村垣善浩、伊関洋 (2011)「脳溝に注目した正常日本人脳MRI解析と臨床応用への試み」CI研究33:21-29.
Yoshimitsu K, Maruyama T, Muragaki Y, Suzuki T, Saito T, Nitta M, Tanaka M, Chernov M, Tamura M, Ikuta S, Okamoto J, Okada Y, Iseki H (2011) Wireless Modification of the Intraoperative Examination Monitor for Awake Surgery - Technical Note ? Neurologia medico-chirurgica 51:472-476. (DOI:10.2176/nmc.51.472)
Narita H (2012) Phase cycles in service of projection-free syntax,” Angel J. Gallego, ed., Phases: developing the framework, Mouton de Gruyter. 125-172.
成田広樹、福井直樹 (2011)「言語を巡る「何」と「なぜ」―生成文法の視点から―」 日本語学 30:24-33.
Inubushi T, Iijima K, Koizumi M, Sakai KL (2012) Left Inferior Frontal Activations Depending on the Canonicity Determined by the Argument Structures of Ditransitive Sentences: An MEG Study. PLOS One 7:e37192. (DOI:10.1371/journal.pone.0037192)
Ohta S, Fukui N, Sakai KL (2013) Syntactic Computation in the Human Brain: The Degree of Merger as a Key Factor. PLOS One 8:e56230. (DOI:10.1371/journal.pone.0056230)
Muragaki Y, Chernov M, Yoshimitsu K, Suzuki T, Iseki H, Maruyama T, Tamura M, Ikuta S, Nitta M, Watanabe A, Saito T, Okamoto J, Niki C, Hayashi M, Takakura K (2012) Information-Guided Surgery of Intracranial Gliomas: Overview of an Advanced Intraoperative Technology, J Healthc Eng 3:551-569. (DOI:10.1260/2040-2295.3.4.551)
Tamura M, Konishi Y, Tamura N, Hayashi M, Nakao N, Uematsu Y, Itakura T, Régis J, Mangin JF, Muragaki Y, Iseki H (2013) Usefulness of Leksell GammaPlan for preoperative planning of brain tumor resection: delineation of the cranial nerves and fusion of the neuroimaging data, including diffusion tensor imaging. Acta Neurochirurgica Suppl 116:179-185. (DOI:10.1007/978-3-7091-1376-9_27)
Narita H, Kato T, Zushi M (2013). A Review of "Anna Maria Di Sciullo and Cedric Boeckx, eds. (2011) The Biolinguistic Enterprise: New Perspectives on the Evolution and Nature of the Human Language Faculty (Oxford Studies in Biolinguistics), Oxford University Press". English Linguistics 30.
Fukui N, Narita H. Merge, labeling, and projection. In Andrew Carnie, Dan Siddiqi, and Yosuke Sato, eds., Routledge Handbook of Syntax. London: Routledge, to appear.
高井チーム
Kurooka T, Yamamoto Y, Takai Y, Sakisaka T (2011) Dual regulation of RA-Rho-GAP activity by phosphatidic acid and Rap1 during neurite outgrowth. J Biol Chem 286:6832-6843. (DOI:10.1074/jbc.M110.183772)
Narita H, Yamamoto Y, Suzuki M, Miyazaki N, Yoshida A, Kawai K, Iwasaki K, Nakagawa A, Takai Y, Sakisaka T (2011) Crystal structure of the cis-Dimer of nectin-1: implications for the architecture of cell-cell junctions. J Biol Chem 286:12659-12669. (DOI:10.1074/jbc.M110.197368)
Narita H, Nakagawa A, Yamamoto Y, Sakisaka T, Takai Y, Suzuki M (2011) Refolding, crystallization and preliminary X-ray crystallographic study of the whole extracellular regions of nectins. Acta Cryst F67:344-348. (DOI:10.1107/S174430911100337X)
Togashi H, Kominami K, Waseda M, Komura H, Miyoshi J, Takeichi M, Takai Y (2011) Nectins Establish a Checkerboard-Like Cellular Pattern in the Auditory Epithelium. Science 333:1144-1147. (DOI:10.1126/science.1208467)
Kurita S, Ogita H, Takai Y (2011) Cooperative role of the nectin-nectin and nectin-afadin interactions in the formation of the nectin-based cell-cell adhesion. J Biol Chem 286:36297-36303. (DOI:10.1074/jbc.M111.261768)
Matsui C, Inoue E, Kakita A, Arita K, Deguchi-Tawarada M, Togawa A, Yamada A, Takai Y, Takahashi, H (2012) Involvement of the γ-secretase-mediated EphA4 signaling pathway in synaptic pathogenesis of Alzheimer’s disease. Brain Pathology 22:776-787. (DOI:10.1111/j.1750-3639.2012.00587.x)
尾藤チーム
Watanabe S, Mizukami S, Hori Y, Kikuchi K (2010) Multicolor Protein Labeling in Living Cells Using Mutant b-Lactamase-Tag Technology. Bioconjugate Chemistry 21:2320-2326. (DOI:10.1021/bc100333k)
Zhang Y, Fukushima H, Kida S (2011) Induction and requirement of gene expression in the anterior cingulate cortex and medial prefrontal cortex for the consolidation of inhibitory avoidance memory. Mol Brain 4:4. (DOI:10.1186/1756-6606-4-4)
Kim R, Moki R, Kida S (2011) Molecular mechanisms for the destabilization and restabilization of reactivated spatial memory in the Morris water maze. Mol Brain 4:9. (DOI:10.1186/1756-6606-4-9)
Okuno H (2011) Regulation and function of immediate-early genes in the brain: beyond neuronal activity markers. Neurosci Res 69:175-186. (DOI:10.1016/j.neures.2010.12.007)
Komatsu T, Johnsson K, Okuno H, Bito H, Inoue T, Nagano T, Urano Y (2011) Real-time measurements of protein dynamics using fluorescence activation-coupled protein labeling (FAPL) method. J Amer Chem Soc 133:6745-6751 (DOI:10.1021/ja200225m)
Hosoda H, Miyao T, Uchida S, Sakai S, Kida S (2011) Development of tightly regulated tetracycline-dependent transcriptional activator and repressor co-expression system for the strong induction of transgene expression. Cytotechnology 63:211-216. (DOI:10.1007/s10616-011-9335-z)
Sadhu KK, Mizukami S, Watanabe S, Kikuchi K (2010) Turn-on fluorescence switch involving aggregation and elimination processes for β-lactamase-tag. Chemical Communications 46:7403-7405. (DOI:10.1039/C0CC02432E)
Mizukami S, Matsushita H, Takikawa R, Sugihara F, Shirakawa M, Kikuchi K (2011) 19F MRI detection of β-galactosidase activity for imaging of gene expression, Chem Sci 2:1151-1155. (DOI:10.1039/C1SC00071C)
Yoshimura A, Mizukami S, Hori Y, Kikuchi K (2011) Cell Surface Protein Labeling with Luminescent Nanoparticles via Biotinylation Using Mutant beta-Lactamase-tag Technology. ChemBioChem 12:1031-1034. (DOI:10.1002/cbic.201100021)
Sadhu KK, Mizukami S, Watanabe S, Kikuchi K (2011) Sequential ordering among multicolor fluorophores for protein labeling facility via aggregation-elimination based β-lactam probes. Molecular BioSystems 7:1766-1772. (DOI:10.1039/C1MB05013C)
Suzuki A, Fukushima H, Mukawa T, Toyoda H, Wu LJ, Zhao MG, Hui X, Shang Y, Endoh K, Iwamoto T, Mamiya N, Okano E, Hasegawa H, Mercaldo V, Zhang Y, Maeda R., Ohta M, Josselyn SA, Zhuo M, Kida S (2011) Up-regulation of CREB-mediated transcription enhances both short- and long-term memory. J Neurosci 31:8786-8802. (DOI:10.1523/JNEUROSCI.3257-10.2011)
Tse D, Takeuchi T, Kakeyama M, Kajii Y, Okuno H, Tohyama C, Bito H, Morris RGM (2011) Schema-dependent gene activation and memory encoding in neocortex. Science 333:891-895. (DOI:10.1126/science.1205274)
Watanabe S, Mizukami S, Akimoto Y, Hori Y, Kikuchi K (2011) Intracellular Protein Labeling with Prodrug-Like Probes Using a Mutant β-Lactamase Tag. Chem Eur J 17:8342-8349. (DOI:10.1002/chem.201100973)
Mizukami S, Yamamoto T, Yoshimura A, Watanabe S, Kikuchi K (2011) Covalent Protein Labeling with a Lanthanide Complex and its Application to Photoluminescence Lifetime-based Multicolor Bioimaging. Angew Chem Int Ed 50:8750 -8752. (DOI:10.1002/ange.201103775)
Kowada T, Kikuta J, Kubo A, Ishii M, Maeda H, Mizukami S, Kikuchi K (2011) In Vivo Fluorescence Imaging of Bone-Resorbing Osteoclasts. J Am Chem Soc 133:17772-17776. (DOI:10.1021/ja2064582)
Sadhu KK, Mizukami S, Lanam CR, Kikuchi K (2012) Fluorogenic Protein Labeling through Photoinduced Electron Transfer-Based BL-tag Technology, Chem Asian J 7:272-276. (DOI:10.1002/asia.201100647)
Mizukami S, Watanabe S, Akimoto Y, Kikuchi K. (2012) No-Wash Protein Labeling with Designed Fluorogenic Probes and Application to Real-Time Pulse-Chase Analysis. J Am Chem Soc 134:1623-1629. (DOI:10.1021/ja208290f)
Okada S, Mizukami S, Kikuchi K (2012) Switchable MRI contrast agents based on morphological changes of pH-responsive polymers. Bioorg Med Chem 20:769-774. (DOI:10.1016/j.bmc.2011.12.005)
Terai T, Kikuchi K, Urano Y, Kojima H, Nagano T (2012) A long-lived luminescent probe to sensitively detect arylamine N-acetyltransferase (NAT) activity of cells. Chem Commun 48:2234-2236. (DOI:10.1039/C2CC17622J)
Sadhu KK, Mizukami S, Lanam CR, Kikuchi K. (2012) A New Approach for Fluorogenic Protein Labeling Via Photoinduced ElectronTransfer Based BL-tag Protein Labeling Method. Chem Asia J 7:272-276. (DOI:10.1002/asia.201290001)
Nomoto M, Takeda Y, Uchida S, Mitsuda K, Enomoto H, Saito K, Choi T, Watabe AM, Kobayashi S, Masushige S, Manabe T, Kida S (2012) Dysfunction of the RAR/RXR signaling pathway in the forebrain impairs hippocampal memory and synaptic plasticity. Mol Brain 5:8. (DOI:10.1186/1756-6606-5-8)
Hori Y, Nakaki K, Sato M, Mizukami S, Kikuchi K (2012) Development of protein-labeling probes with a redesigned fluorogenic switch based on intramolecular association for no-wash live-cell imaging. Angew Chem Int Ed Engl 51:5611-5614. (DOI:10.1002/anie.201200867)
Terai T, Ito H, Kikuchi K, Nagano T (2012) Salicylic-acid derivatives as antennae for ratiometric luminescent probes based on lanthanide complexes. Chemistry 18:7377-7381. (DOI:10.1002/chem.201200610)
Okuno H, Akashi K, Ishii Y, Yagishita-Kyo N, Suzuki K, Nonaka M, Kawashima T, Fujii H, Takemoto-Kimura S, Abe M, Natsume R, Chowdhury S, Sakimura K, Worley PF, Bito H (2012) Inverse synaptic tagging of inactive synapses via dynamic interaction of Arc/Arg3.1 with CaMKIIβ. Cell 149:886-898. (DOI:10.1016/j.cell.2012.02.062)
→東京大学との共同発表
→ライフサイエンス新着論文レビュー「ArcはCa2+/カルモジュリン依存性キナーゼIIβとの相互作用により不活性なシナプスに集積しAMPA型グルタミン酸受容体のエンドサイトーシスにはたらく」
Kim R, Okuno H, Bito H (2012) Deciphering the molecular rules governing synaptic targeting of the memory related protein Arc. Commun Integr Biol 5:496-498. (DOI:10.4161/cib.20853)
Wang H, Morishita Y, Miura D, Naranjo JR, Kida S, Zhuo M (2012) Roles of CREB in the regulation of FMRP by group I metabotropic glutamate receptors in cingulate cortex. Mol Brain 5:27. (DOI:10.1186/1756-6606-5-27)
Baba R, Hori Y, Mizukami S, Kikuchi K (2012) Development of a fluorogenic probe with a transesterification switch for detection of histone deacetylase activity. J Am Chem Soc 134:14310-14313. (DOI:10.1021/ja306045j)
Zeng Z, Mizukami S, Kikuchi K (2012) Simple and real-time colorimetric assay for glycosidases activity using functionalized gold nanoparticles and its application for inhibitor screening. Anal Chem 84:9089-9095. (DOI:10.1021/ac301677v)
Watakabe A, Kato S, Kobayashi K, Takaji M, Nakagami Y, Sadakane O, Ohtsuka M, Hioki H, Kaneko T, Okuno H, Kawashima T, Bito H, Kitamura Y, Yamamori T (2012) Visualization of cortical projection neurons with retrograde TET-off lentiviral vector. PLoS One 7:e46157. (DOI:10.1371/journal.pone.0046157)
Sadhu KK, Mizukami S, Yoshimura A, Kikuchi K (2013) pH induced dual "OFF-ON-OFF" switch: influence of a suitably placed carboxylic acid. Org Biomol Chem. 11:563-568. (DOI:10.1039/c2ob26630j)
Dhara K, Hori Y, Baba R, Kikuchi K (2012) A fluorescent probe for detection of histone deacetylase activity based on aggregation-induced emission. Chem Commun (Camb). 48:11534-6. (DOI:10.1039/c2cc36591j)
Endo T, Kakeyama M, Uemura Y, Haijima A, Okuno H, Bito H, Tohyama C (2012) Executive function deficits and social-behavioral abnormality in mice exposed to a low dose of dioxin in utero and via lactation. PLoS One. 7:e50741. (DOI:10.1371/journal.pone.0050741)
Kida S (2012) A Functional Role for CREB as a Positive Regulator of Memory Formation and LTP. Exp Neurobiol 21:136-140. (DOI:10.5607/en.2012.21.4.136)
Descalzi G, Fukushima H, Suzuki A, Kida S, Zhuo M (2012) Genetic enhancement of neuropathic and inflammatory pain by forebrain upregulation of CREB-mediated transcription. Mol Pain 8:90. (DOI:10.1186/1744-8069-8-90)
Fujii H, Inoue M, Okuno H, Sano Y, Takemoto-Kimura S, Kitamura K, Kano M, Bito H (2013) Nonlinear decoding and asymmetric representation of neuronal input information by CaMKIIα and calcineurin. Cell Reports in press. (DOI:10.1016/j.celrep.2013.03.033)
→東京大学よりプレス発表
山下チーム
Nakamura Y, Fujita Y, Ueno M, Takai T, Yamashita T (2011) Paired immunoglobulin-like receptor B knockout does not enhance axonal regeneration or locomotor recovery after spinal cord injury. J Biol Chem 286:1876-1883. (DOI:10.1074/jbc.M110.163493)
Hagihara M, Endo M, Hata K, Higuchi C, Takaoka K, Yoshikawa H, Yamashita T (2011) Neogenin: A receptor for bone morphogenetic proteins. J Biol Chem 286:5157-5165. (DOI:10.1074/jbc.M110.180919)
Ohara R, Hata K, Yasuhara N, Mehmood R, Yoneda Y, Nakagawa M, Yamashita, T (2011) Axotomy induces axonogenesis in hippocampal neurons by a mechanism dependent on Importin β. Biochem Biophys Res Commun 405:697-702. (DOI:10.1016/j.bbrc.2011.01.108)
Fujita Y, Endo S, Takai T, Yamashita T (2011) Myelin suppresses axon regeneration by PIR-B/SHP-mediated inhibition of Trk activity. EMBO J 30:1389-1401. (DOI:10.1038/emboj.2011.55)
→大阪大学との共同発表
Lee S, Ueno M, Yamashita T (2011) Axonal remodeling for motor recovery after traumatic brain injury requires downregulation of γ-aminobutyric acid signaling. Cell Death Dis 2:e133. (DOI:10.1038/cddis.2011.16)
Muramatsu R, Kubo T, Mori M, Nakamura Y, Fujita Y, Akutsu T, Okuno T, Taniguchi J, Kumanogoh A, Yoshida M, Mochizuki H, Kuwabara S, Yamashita T (2011) RGMa modulates T cell responses and is involved in autoimmune encephalomyelitis. Nature Medicine 17:488-494. (DOI:10.1038/nm.2321)
→大阪大学よりプレス発表
→ライフサイエンス新着論文レビュー「RGMはT細胞の活性化を制御し自己免疫性脳脊髄炎に関与する」
Omoto S, Ueno M, Mochio S, Yamashita T (2011) Corticospinal tract fibers cross the ephrin-B3?negative part of the midline of the spinal cord after brain injury. Neurosci Res 69:187-195. (DOI:10.1016/j.neures.2010.12.004)
Ohara R, Fujita Y, Hata K, Nakagawa M, Yamashita T (2011) Axotomy induces axonogenesis in hippocampal neurons through STAT3. Cell Death Dis 2:e175. (DOI:10.1038/cddis.2011.59)
Ueno M, Yamashita T (2011) Kinematic analyses reveal impaired locomotion following injury of the motor cortex in mice. Exp Neurol 230:280-290. (DOI:10.1016/j.expneurol.2011.05.006)
Okamura Y, Kohmura E, Yamashita T (2011) TACE cleaves neogenin to desensitize cortical neurons to the repulsive guidance molecule. Neurosci Res 71:63-70. (DOI:10.1016/j.neures.2011.05.012)
Fujita Y, Takashima R, Endo S, Takai T, Yamashita T (2011) The p75 receptor mediates axon growth inhibition through an association with PIR-B. Cell Death Dis 2:e198. (DOI:10.1038/cddis.2011.85)
Kitayama M, Ueno M, Itakura T, Yamashita T (2011) Activated microglia inhibit axonal growth through RGMa. PLoS ONE 6:e25234. (DOI:10.1371/journal.pone.0025234)
Yoshimura K, Ueno M, Lee S, Nakamura Y, Sato A, Yoshimura K, Kishima H, Yoshimine T, Yamashita T (2011) C-Jun N-terminal kinase induces axonal degeneration and limits motor recovery after spinal cord injury in mice. Neurosci Res 71:266-277. (DOI:10.1016/j.neures.2011.07.1830)
Itokazu T, Fujita Y, Takahashi R, Yamashita T (2012) Identification of the neogenin-binding site on the repulsive guidance molecule a. PLoS ONE 7:e32791. (DOI:10.1371/journal.pone.0032791)
Kurihara D, Yamashita T (2012) Chondroitin sulfate proteoglycans downregulate spine formation in cortical neurons by targeting tropomyosin-related kinase B (TrkB) protein. J Biol Chem 287:13822-13828. (DOI:10.1074/jbc.M111.314070)
Ueno M, Hayano Y, Nakagawa H, Yamashita T (2012) Intraspinal rewiring of the corticospinal tract requires target-derived brain-derived neurotrophic factor and compensates lost function after brain injury. Brain 135:1253-1267. (DOI:10.1093/brain/aws053)
→大阪大学よりプレス発表
Jin X, Ishii H, Bai Z, Itokazu T, Yamashita T (2012) Temporal changes in cell marker expression and cellular infiltration in a controlled cortical impact model in adult male C57BL/6 mice. PLoS ONE 7:e41892. (DOI:10.1371/journal.pone.0041892)
Ishii H, Jin X, Ueno M, Tanabe S, Kubo T, Serada S, Naka T, Yamashita T (2012) Adoptive transfer of Th1-conditioned lymphocytes promotes axonal remodeling and functional recovery after spinal cord injury. Cell Death Dis 3:e363. (DOI:10.1038/cddis.2012.106)
Muramatsu R, Takahashi C, Miyake S, Fujimura H, Mochizuki H, Yamashita, T (2012) Angiogenesis induced by CNS inflammation promotes neuronal remodeling through vessel-derived prostacyclin. Nature Medicine 18:1658-1664. (DOI:10.1038/nm.2943)
→大阪大学との共同発表
→ライフサイエンス新着論文レビュー「新生した血管から放出されるプロスタサイクリンは神経回路の再生を促進する」
Fujiki R, Sato A, Hata K, Tashiro F, Yasuhara Y, Miyazaki J, Yoneda Y, Fujitani M, Yamashita T (2013) Improvement in protocol to generate homogeneous glutamatergic neurons from mouse embryonic stem cells reduced apoptosis. Biochem Biophys Res Commun 430:604-609. (DOI:10.1016/j.bbrc.2012.11.106)
Nakagawa H, Ueno M, Itokazu T, Yamashita T (2013) Bilateral movement training promotes axonal remodeling of the corticospinal tract and recovery of motor function following traumatic brain injury in mice. Cell Death Dis 4:e534. (DOI:10.1038/cddis.2013.62)
Ueno M, Fujita Y, Tanaka T, Nakamura Y, Kikuta J, Ishii M, Yamashita T (2013) Layer V cortical neurons require microglial support for survival during postnatal development. Nat Neurosci (DOI:10.1038/nn.3358)
→大阪大学との共同発表
→ライフサイエンス新着論文レビュー「脳の発達期においてミクログリアは大脳皮質第5層のニューロンの生存に寄与する」
Uesugi N, Kimura Y, Yamashita T (2013) Suppression of the p75 receptor signal attenuates the effect of ephrin-B3 and promotes axonal regeneration of the injured optic nerve. Cell Death Dis (in press)
Tanaka T, Fujita Y, Ueno M, Shultz LD, Yamashita T (2013) Suppression of SHP-1 promotes functional corticospinal tract rewiring after brain injury. Cell Death Dis (in press)