Development of Catalytic Transformation of Strong Sigma-Bonds

Principal Investigator

Mamoru TOBISU (Professor, Graduate School of Engineering, Osaka University)

Outline of the Project

Synthetic chemists depend heavily on the transformation of reactive chemical bonds, such as carbon-halogen bonds and p-bonds. To overcome this dependence, our research program focuses on the development of catalyst technologies that enable the transformation of strong chemical bonds and thus significantly diversify the synthetic methodologies.

Particular emphasis will be on the activation of inert sigma-bonds other than well-studied C-H bonds: C-O bond activation of anisoles and C-heteroatom bond activation for heterocycle synthesis. Recent works include the palladium-catalyzed synthesis of phosphole derivatives via C-P and C-H bond cleavages. This method enables the synthesis of a series of phosphole derivatives that are of interest in the field of material chemistry from simple and readily available tertiary phosphines.

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