Development of Catalytic Asymmetric C-C Bond Forming Reactions for Organofluorine Compounds and Industrial Applications

Principal Investigator

Koichi MIKAMI (Professor, Tokyo Institute of Technology)

Co-Principal Investigator

Hideki AMII (Professor, Gunma University)
Norio SHIBATA (Professor, Nagoya Institute of Technology)

Outline of the Project

Catalytic asymmetric reactions, catalytic asymmetric C-C bond forming (CCF) reactions in particular which are of central importance in construction of chiral 3-D carbon skeletons of organic molecules, are the green and frontier technology of molecular transformation for sustainable development. This research project aims at the development of these technologies for catalytic asymmetric activation of chemically inert C-H, C-C, and C-F bonds as well as relatively reactive C-Si (as a super proton) bonds for asymmetric C-C bond formation. Special attention is focused on the development and industrial application of these technologies for the design and synthesis of organofluorine compounds which are essential in current development of new drugs and materials.

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