Development of New Methodology for Environmentally Friendly Transformation

Principal Investigator

Naoto CHATANI (Professor, Osaka University) 

Outline of the Project

The functionalization of C-H bonds, the most common bond in organic compounds would clearly be one of most important environmentally friendly and ideal synthetic method, if it could be accomplished without the need for additional intermediate steps. The functionalization of C-H bonds affords a great opportunity for the direct formation of a wide variety of chemical bonds from C-H bonds. The aim of this project is to produce a breakthrough that will permit the catalytic activation of C-H bonds and to develop straightforward synthetic transformations of C-H bonds. A final goal is that the catalytic transformation of C-H bonds would clearly be more useful than the conventional cross-coupling reactions. One of the reliable methods for transforming C-H bonds is chelation-assistance. The design of new directing groups continues to be important in terms of exploring new types of transformations of C-H bonds that cannot be achieved using currently known directing groups. Our plans include the development of new catalytic reactions by taking advantage of chelation assistance in conjunction with new types of directing groups. 

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