Asymmetric Carbon-Hydrogen Bond Transformation Using Metal Carbene Complex, for Efficient Carbon-Carbon Bond Formation

Principal Investigator

Tsutomu KATSUKI(Principal Investigator, Kyushu University, International Institute of carbon-neutral energy research)

Outline of the Project

Organic compounds consist of a carbon skeleton, to which many hydrogen atoms are attached. Thus, specific carbon-hydrogen bond transformation to carbon-carbon bond provides various carbon skeletons, and it is a useful tool for the synthesis of versatile organic compounds. In this study, we develop stereo- and regioselective carbene C-H insertion using a transition metal complex as catalyst, which conduces to short-step synthesis of useful compounds with less use of protecting groups. On the other hand, hydroxyaromatic compounds are abundant in the biological sphere. Thus, we also examine asymmetric oxidative dearomatization of hydroxy aromatic compounds with carbon-carbon bond formation to provide useful multifunctional cyclic enone derivatives, which are versatile chiral building blocks in organic synthesis.

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